Synthesis of microcolin analogs using trimethylsilylated lactams

Article abstract of DOI:10.1016/S0040-4039(97)00336-5

The synthesis of microcolin analogs is described using an approach that could be of considerable practical interest for structure-activity studies on microcolin and related peptides. This synthetic pathway is more efficient than the methods reported to date, and allows the variation of the Xaa-pyrrolin-2-one unit of these molecules, which has been shown to be crucial for the biological activity.