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18977-36-1

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18977-36-1 Usage

Description

2,6-bis(m-nitrobenzylidene)cyclohexan-1-one is a complex chemical compound derived from cyclohexanone, featuring two m-nitrobenzylidene groups attached at the 2 and 6 positions. 2,6-bis(m-nitrobenzylidene)cyclohexan-1-one is known for its photochromic properties, which allow it to change color upon exposure to light, and its potential applications in materials science and biomedical fields.

Uses

Used in Organic Synthesis:
2,6-bis(m-nitrobenzylidene)cyclohexan-1-one is utilized as a building block in the synthesis of various organic molecules, contributing to the development of new chemical compounds with diverse applications.
Used in Materials Science:
Due to its photochromic properties, 2,6-bis(m-nitrobenzylidene)cyclohexan-1-one is employed in the creation of light-sensitive materials and devices, which can change their properties or appearance when exposed to different light conditions.
Used in Photodynamic Therapy:
The m-nitrobenzylidene groups present in 2,6-bis(m-nitrobenzylidene)cyclohexan-1-one make it a promising candidate for use in photodynamic therapy, a medical treatment that involves the use of light and photosensitizing agents to target and destroy diseased cells.
Used in Biomedical Applications:
Beyond photodynamic therapy, the unique properties of 2,6-bis(m-nitrobenzylidene)cyclohexan-1-one also lend it to other biomedical applications, where its light-responsive characteristics can be harnessed for various therapeutic and diagnostic purposes.

Check Digit Verification of cas no

The CAS Registry Mumber 18977-36-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,9,7 and 7 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 18977-36:
(7*1)+(6*8)+(5*9)+(4*7)+(3*7)+(2*3)+(1*6)=161
161 % 10 = 1
So 18977-36-1 is a valid CAS Registry Number.
InChI:InChI=1/C20H16N2O5/c23-20-16(10-14-4-1-8-18(12-14)21(24)25)6-3-7-17(20)11-15-5-2-9-19(13-15)22(26)27/h1-2,4-5,8-13H,3,6-7H2

18977-36-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,6-bis[(3-nitrophenyl)methylidene]cyclohexan-1-one

1.2 Other means of identification

Product number -
Other names EINECS 242-711-0

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18977-36-1 SDS

18977-36-1Relevant articles and documents

Green, rapid, and highly efficient syntheses of α,α′-bis[(aryl or allyl)idene]cycloalkanones and 2-[(aryl or allyl)idene]-1-indanones as potentially biologic compounds via solvent-free microwave-assisted Claisen–Schmidt condensation catalyzed by MoCl5

Bakhshi, Reza,Zeynizadeh, Behzad,Mousavi, Hossein

, p. 623 - 637 (2019/08/26)

A new, green, and highly efficient protocol for the expeditious preparation of some α,α′-bis[(aryl or allyl)idene]cycloalkanones and 2-[(aryl or allyl)idene]-1-indanones via a simple microwave-assisted Claisen–Schmidt condensation reaction catalyzed by MoCl5 was successfully developed. Outstanding features of the current methodology include the use of solvent-free conditions, simple operation, use of a very inexpensive and available catalyst, low catalyst loading, short reaction times, high yields of the pure products, no harmful by-products, easy workup, and also the applicability of microwave irradiation as a clean source of energy. Furthermore, a gram-scale reaction was successfully conducted, proving the scalability of this current Claisen–Schmidt condensation reaction.

Synthesis, characterization, crystal structure of novel bis-thiomethylcyclohexanone derivatives and their inhibitory properties against some metabolic enzymes

Bi?er, Abdullah,Taslimi, Parham,Yakal?, Gül,Gül?in, Ilhami,Serdar Gültekin, Mehmet,Turgut Cin, Günseli

, p. 393 - 404 (2018/11/23)

In this study, a series of novel bis-thiomethylcyclohexanone compounds (3a–3j) were synthesized by the addition of thio-Michael to the bis-chalcones under mild reaction conditions. The bis-thiomethylcyclohexanone derivatives (bis-sulfides) were characterized by 1H NMR, 13C NMR, FTIR and elemental analysis techniques. Furthermore, the molecular and crystal structures of 3h, 3i and 3j compounds were determined by single crystal X-ray diffraction studies. In this study, X-ray crystallography provided an alternative and often-complementary means for elucidating functional groups at the enzyme inhibitory site. Acetylcholinesterase (AChE) is a member of the hydrolase protein super family and has a significant role in acetylcholine-mediated neurotransmission. Here, we report the synthesis and determining of novel bis-thiomethylcyclohexanone compounds based hybrid scaffold of AChE inhibitors. The newly synthesized bis-thiomethylcyclohexanone compounds showed Ki values of in range of 39.14–183.23 nM against human carbonic anhydrase I isoenzyme (hCA I), 46.03–194.02 nM against human carbonic anhydrase II isoenzyme (hCA II), 4.55–32.64 nM against AChE and 12.77–37.38 nM against butyrylcholinesterase (BChE). As a result, novel bis-thiomethylcyclohexanone compounds can have promising anti Alzheimer drug potential and record novel hCA I, and hCA II enzymes inhibitor.

An efficient green approach to aldol and cross-aldol condensations of ketones with aromatic aldehydes catalyzed by nanometasilica disulfuric acid in water

Nakhaei,Morsali,Davoodnia

, p. 1073 - 1078 (2017/06/29)

Aldol and cross-aldol condensations of aromatic aldehydes with various ketones in the presence of nanometasilica disulfuric acid (NMSDSA) as heterogeneous catalyst are presented. The catalyst was prepared according to the developed earlier method using inexpensive and readily available starting materials. The highly active catalyst gave excellent yields of the desired aldol products without self-condensation reaction taking place. Reaction times were short, the procedure and work-up were simple, and no volatile or hazardous organic solvents were involved. The catalyst could be recovered three times with only slight reduction in activity.

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