189807-79-2Relevant academic research and scientific papers
N-carbamoyl analogs of Zafirlukast: Potent receptor antagonists of leukotriene D4
Brown, Matthew F.,Marfat, Anthony,Antognoli, Gerard,Chambers, Robert J.,Cheng, John B.,Damon, David B.,Liston, Theodore E.,McGlynn, Molly A.,O'Sullivan, Stacie P.,Owens, Brian S.,Pillar, Joann S.,Shirley, John T.,Watson, John W.
, p. 2451 - 2456 (1998)
Exploration of the indole nitrogen region of Zafirlukast (1) has uncovered a potent series of cysteinyl leukotriene D4 (LTD4) antagonists. These studies showed that a variety of functionality could be incorporated in this region of the molecule without sacrificing potency. Efforts to exploit this site in order to improve oral efficacy are discussed.
Indole carbamates as leukotriene antagonists
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, (2008/06/13)
Compounds of the formula STR1 wherein R1 AND R2 are as defined, useful in the treatment of asthma, rheumatoid arthritis, osteoarthritis, bronchitis, chronic obstructive airways diseases, psoriasis, allergic rhinitis, atopic dermatiti
