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Difluorochloromethane
Cas No: 75-45-6
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Chlorodifluoromethane
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Methane,chlorodifluoro-
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CAS NO.75-45-6 Methane,chlorodifluoro-
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Difluorochloromethane? CAS NO 75-45-6 from China supplier factory price
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Difluorochloromethane CAS NO.75-45-6
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Difluorochloromethane
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75-45-6 Usage

InChI:InChI=1/CHClF2/c2-1(3)4/h1H

75-45-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Difluorochloromethane

1.2 Other means of identification

Product number -
Other names difluoromonochloromethane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Functional fluids (closed systems),Intermediates,Laboratory chemicals
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:75-45-6 SDS

75-45-6Synthetic route

chlorodifluoromethyllithium

chlorodifluoromethyllithium

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol In N,N,N,N,N,N-hexamethylphosphoric triamide decompn. in the presence of CF3CH2OH at reflux temp., 12 h;100%
In N,N,N,N,N,N-hexamethylphosphoric triamide
dichloromethane
75-09-2

dichloromethane

ammonia
7664-41-7

ammonia

A

hydrogen cyanide
74-90-8

hydrogen cyanide

B

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
nickel In neat (no solvent) steady-state flow reaction over Ni catalyst at 723 K;A 98.3%
B 0.6%
nickel In neat (no solvent) steady-state flow reaction over Ni catalyst at 673 K;A 75.4%
B 1.7%
chloropentafluoroacetone
79-53-8

chloropentafluoroacetone

A

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

B

trifluoroacetyl fluoride
354-34-7

trifluoroacetyl fluoride

C

2,2-difluoroacetyl fluoride
2925-22-6

2,2-difluoroacetyl fluoride

D

C3HClF6O
152239-89-9

C3HClF6O

Conditions
ConditionsYield
With chlorine monofluoride; cesium fluoride 1.) -140 degC to -75 degC over 6 h, 2.) -75 degC, 2 h; Further byproducts given;A n/a
B n/a
C n/a
D 90%
dichloromethane
75-09-2

dichloromethane

ammonia
7664-41-7

ammonia

A

hydrogen cyanide
74-90-8

hydrogen cyanide

B

Difluoromethane
75-10-5

Difluoromethane

C

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

D

carbon dioxide
124-38-9

carbon dioxide

E

carbon monoxide
201230-82-2

carbon monoxide

Conditions
ConditionsYield
nickel titanate In neat (no solvent) steady-state flow reaction over NiTO3*6H2O catalyst at 773 K, further by-product is CFH3 (yield 0.3 %);A 81.8%
B 0.1%
C 0.6%
D 10.4%
E 6.8%
nickel titanate In neat (no solvent) steady-state flow reaction over NiTO3*6H2O catalyst at 823 K, further by-product is CFH3 (yield 0.4 %);A 66.2%
B 0.2%
C 1.4%
D 12.9%
E 18.8%
With catalyst: Pt/C In neat (no solvent) steady-state flow reaction over Pt/C catalyst at 821 K, a further by-product is CFH3 (yield 0.2 %);A 64.6%
B 0.3%
C 0.2%
D 0.6%
E 0.8%
sodium chlorodifluoroacetate
1895-39-2

sodium chlorodifluoroacetate

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃;68%
dichloromethane
75-09-2

dichloromethane

ammonia
7664-41-7

ammonia

A

hydrogen cyanide
74-90-8

hydrogen cyanide

B

Methyl fluoride
593-53-3

Methyl fluoride

C

Difluoromethane
75-10-5

Difluoromethane

D

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

E

carbon dioxide
124-38-9

carbon dioxide

Conditions
ConditionsYield
With catalyst: Pt/C In neat (no solvent) steady-state flow reaction over Pt/C catalyst at 769 K;A 53.4%
B 0.3%
C 0.5%
D 7.6%
E 0.5%
2,2-difluoro-2-(fluorosulfonyl)acetic acid
1717-59-5

2,2-difluoro-2-(fluorosulfonyl)acetic acid

sodium 4-iodo-benzoate
1005-30-7

sodium 4-iodo-benzoate

A

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

B

4-Iodo-benzoic acid difluoromethyl ester
120608-87-9

4-Iodo-benzoic acid difluoromethyl ester

Conditions
ConditionsYield
With potassium chloride In acetonitrile at 50℃; for 2.5h;A n/a
B 45%
Chlorotrifluoroethylene
79-38-9

Chlorotrifluoroethylene

C3HClF6O
152239-89-9

C3HClF6O

A

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

B

trifluoroacetyl fluoride
354-34-7

trifluoroacetyl fluoride

C

2,2-difluoroacetyl fluoride
2925-22-6

2,2-difluoroacetyl fluoride

D

2-(2,2-Dichloro-1,1,2-trifluoro-ethoxy)-1,1,1,2,3,3-hexafluoro-propane

2-(2,2-Dichloro-1,1,2-trifluoro-ethoxy)-1,1,1,2,3,3-hexafluoro-propane

Conditions
ConditionsYield
In trichlorofluoromethane for 18h; -135 degC to 25 degC; Further byproducts given;A n/a
B n/a
C n/a
D 40%
chlorodifluoroiodomethane
420-49-5

chlorodifluoroiodomethane

potassium hydroxide

potassium hydroxide

A

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

B

potassium carbonate
584-08-7

potassium carbonate

Conditions
ConditionsYield
In ethanol decompn. with alc. KOH at 35°C in 48h;;A 24%
B n/a
In ethanol
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

Triethylgerman
1188-14-3

Triethylgerman

A

Difluoromethane
75-10-5

Difluoromethane

B

dichloromethane
75-09-2

dichloromethane

C

trifluoromethan
75-46-7

trifluoromethan

D

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

E

triethylchlorogermane
994-28-5

triethylchlorogermane

Conditions
ConditionsYield
With ACF. Et3GeH at 25℃; for 72h; Schlenk technique; Inert atmosphere;A n/a
B n/a
C 22%
D 16%
E n/a
methane
34557-54-5

methane

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
With chromium fluoride; hydrogen fluoride; chlorine at 275 - 300℃;
Difluoromethane
75-10-5

Difluoromethane

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
With chlorine
dichloromethane
75-09-2

dichloromethane

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
With hydrogen fluoride; lithium fluoride Electrolysis;
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
With aluminium trichloride Siedetemperatur;
chloroform
67-66-3

chloroform

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
With hydrogen fluoride; antimonypentachloride at 80℃;
With calcium fluoride; silver fluoride at 250℃;
With antimony(III) fluoride
Dichlorodifluoromethane
75-71-8

Dichlorodifluoromethane

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
With hydrogen; platinum at 685℃;
With ammonium persulfate; ammonium formate In N,N-dimethyl-formamide at 30 - 40℃;
With hydrogen Heating;
perfluoropropylene
116-15-4

perfluoropropylene

A

polytetrafluoroethylene
116-14-3

polytetrafluoroethylene

B

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

C

Hexafluoroethane
76-16-4

Hexafluoroethane

Conditions
ConditionsYield
Ambient temperature; Irradiation; also CF2HCl;
dichloromethane
75-09-2

dichloromethane

A

Difluoromethane
75-10-5

Difluoromethane

B

R32
593-70-4

R32

C

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

D

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

E

Dichlorodifluoromethane
75-71-8

Dichlorodifluoromethane

F

trichlorofluoromethane
75-69-4

trichlorofluoromethane

Conditions
ConditionsYield
With xenon difluoride for 48h; Ambient temperature; other halogenocarbons; var. reaction time;
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

A

dichloromethane
75-09-2

dichloromethane

B

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

C

chloroform
67-66-3

chloroform

Conditions
ConditionsYield
With silica gel at 149.9℃; for 6h; Product distribution;
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

A

trifluoromethan
75-46-7

trifluoromethan

B

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
With antimony tetrachloride fluoride at 100℃; Kinetics; kinetic batch run;
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

A

trifluoromethan
75-46-7

trifluoromethan

B

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

C

chloroform
67-66-3

chloroform

Conditions
ConditionsYield
zinc aluminate at 250℃; Product distribution; other temperature;
chloroform
67-66-3

chloroform

A

trifluoromethan
75-46-7

trifluoromethan

B

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

C

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

Conditions
ConditionsYield
With antimony tetrachloride fluoride at 100℃; Kinetics; Product distribution; kinetic behaviour of different fluorinated antimony compound in fluorination (SbCl4F, SbCl5 + SbF3Cl2, SbCl5 + SbF5, SbCl5 + SbF3) at different reaction times;
With antimony tetrachloride fluoride at 100℃; under 7600 Torr; Kinetics; Product distribution; Equilibrium constant; kinetic at three different temperatures (85, 100, 115 deg C) and at different pressures ( 7.3, 8.0, 10.0, 10.5, 13.0, 13.8 atm);
With hydrogen fluoride; antimonypentachloride at 70 - 90℃; under 10746.4 - 10953.3 Torr; Product distribution / selectivity; Heating / reflux;
Dichlorodifluoromethane
75-71-8

Dichlorodifluoromethane

A

hydrogen cyanide
74-90-8

hydrogen cyanide

B

Methyl fluoride
593-53-3

Methyl fluoride

C

Difluoromethane
75-10-5

Difluoromethane

D

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

E

carbon dioxide
124-38-9

carbon dioxide

F

carbon monoxide
201230-82-2

carbon monoxide

Conditions
ConditionsYield
With O3Ti(2-)*Ni(2+); ammonia at 499.9℃; Product distribution; other catalysts;
halon-1211
353-59-3

halon-1211

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
With ammonium persulfate; ammonium formate In N,N-dimethyl-formamide at 30 - 40℃;
With bromine at 349.9℃; Equilibrium constant; different reagent and reactant concentrations and reaction temperatures;
halon-1211
353-59-3

halon-1211

A

bromodifluoromethane
1511-62-2

bromodifluoromethane

B

Difluoromethane
75-10-5

Difluoromethane

C

bromofluoromethane
373-52-4

bromofluoromethane

D

dichloromethane
75-09-2

dichloromethane

E

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

F

1,2-dibromomethane
74-95-3

1,2-dibromomethane

Conditions
ConditionsYield
With hydrogen In gas at 400 - 900℃; under 760 Torr; Rate constant; Product distribution; Mechanism; other reagents; Ea;
Vinylidene fluoride
75-38-7

Vinylidene fluoride

C3HClF6O
152239-89-9

C3HClF6O

A

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

B

trifluoroacetyl fluoride
354-34-7

trifluoroacetyl fluoride

C

2-(2-Chloro-1,1-difluoro-ethoxy)-1,1,1,2,3,3-hexafluoro-propane

2-(2-Chloro-1,1-difluoro-ethoxy)-1,1,1,2,3,3-hexafluoro-propane

D

2-(2-Chloro-2,2-difluoro-ethoxy)-1,1,1,2,3,3-hexafluoro-propane

2-(2-Chloro-2,2-difluoro-ethoxy)-1,1,1,2,3,3-hexafluoro-propane

Conditions
ConditionsYield
In trichlorofluoromethane for 24h; -141 degC to 25 degC; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
polytetrafluoroethylene
116-14-3

polytetrafluoroethylene

A

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

B

2-chloro-1,1,2,2-tetrafluoroethane
354-25-6

2-chloro-1,1,2,2-tetrafluoroethane

C

1,1,1,2-tetrafluoro-2-chloroethane
2837-89-0

1,1,1,2-tetrafluoro-2-chloroethane

D

Octafluorocyclobutane
115-25-3

Octafluorocyclobutane

Conditions
ConditionsYield
With hydrogenchloride at 660℃; under 760 Torr; Mechanism; Ar-diluted mixtures, flow conditions; other temperatures;
Chlorotrifluoroethylene
79-38-9

Chlorotrifluoroethylene

C3HCl2F5O
152239-93-5

C3HCl2F5O

A

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

B

chlorodifluoroacetyl fluoride
354-27-8

chlorodifluoroacetyl fluoride

C

1-Chloro-2-(1,2-dichloro-1,2,2-trifluoro-ethoxy)-1,1,2,3,3-pentafluoro-propane

1-Chloro-2-(1,2-dichloro-1,2,2-trifluoro-ethoxy)-1,1,2,3,3-pentafluoro-propane

D

1-Chloro-2-(2,2-dichloro-1,1,2-trifluoro-ethoxy)-1,1,2,3,3-pentafluoro-propane

1-Chloro-2-(2,2-dichloro-1,1,2-trifluoro-ethoxy)-1,1,2,3,3-pentafluoro-propane

Conditions
ConditionsYield
In trichlorofluoromethane for 18h; -136 degC to 20 degC; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
dichloromethane
75-09-2

dichloromethane

A

Difluoromethane
75-10-5

Difluoromethane

B

R32
593-70-4

R32

C

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

D

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

E

Dichlorodifluoromethane
75-71-8

Dichlorodifluoromethane

Conditions
ConditionsYield
With osmium pentafluoride oxide Product distribution; other transition-metal oxide fluorides;
Dichlorodifluoromethane
75-71-8

Dichlorodifluoromethane

1,1,1,2,2-pentamethyldisilane
812-15-7

1,1,1,2,2-pentamethyldisilane

A

chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

B

trimethylsilan
993-07-7

trimethylsilan

C

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

D

pentamethylchlorodisilane
1560-28-7

pentamethylchlorodisilane

E

dimethylsilicon dichloride
75-78-5

dimethylsilicon dichloride

Conditions
ConditionsYield
at 436.9 - 492.9℃; under 1.5 - 3 Torr; Product distribution; Thermodynamic data; other temp.;
2-[2-(5-bromo-2-hydroxyphenyl)-ethyl]-3-chlorobenzonitrile

2-[2-(5-bromo-2-hydroxyphenyl)-ethyl]-3-chlorobenzonitrile

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

2-[2-(5-bromo-2-difluoromethoxyphenyl)-ethyl]-3-chlorobenzonitrile

2-[2-(5-bromo-2-difluoromethoxyphenyl)-ethyl]-3-chlorobenzonitrile

Conditions
ConditionsYield
With potassium hydroxide In isopropyl alcohol at 20 - 65℃; for 1.1h;100%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

4-bromo-2-vinyloxy-1-methoxybenzene
944334-01-4

4-bromo-2-vinyloxy-1-methoxybenzene

4-bromo-2-cyclopropoxy-1-methoxybenzene
944333-99-7

4-bromo-2-cyclopropoxy-1-methoxybenzene

Conditions
ConditionsYield
With dimethyl zinc(II) In toluene at -40 - 20℃; for 28.25h;100%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

2-Fluoro-6-hydroxybenzonitrile
140675-43-0

2-Fluoro-6-hydroxybenzonitrile

2-(difluoromethoxy)-6-fluorobenzonitrile
221202-14-8

2-(difluoromethoxy)-6-fluorobenzonitrile

Conditions
ConditionsYield
With sodium hydroxide In diethylene glycol dimethyl ether; water at 20 - 65℃;99%
Stage #1: 2-Fluoro-6-hydroxybenzonitrile With sodium hydroxide In 1,2-dimethoxyethane; water at 65℃;
Stage #2: Chlorodifluoromethane In 1,2-dimethoxyethane; water at 20 - 65℃;
With sodium hydroxide In 1,4-dioxane; water at 65℃;
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

(1-Benzyloxymethyl-prop-2-ynyloxy)-tert-butyl-dimethyl-silane

(1-Benzyloxymethyl-prop-2-ynyloxy)-tert-butyl-dimethyl-silane

(1-Benzyloxymethyl-4,4-difluoro-but-2-ynyloxy)-tert-butyl-dimethyl-silane

(1-Benzyloxymethyl-4,4-difluoro-but-2-ynyloxy)-tert-butyl-dimethyl-silane

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran 1.) -78 deg C, 30 min, 2.) -78 deg C, 1 h;98%
m-iodonitrobenzene
645-00-1

m-iodonitrobenzene

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

3-trifluoromethylnitrobenzene
98-46-4

3-trifluoromethylnitrobenzene

Conditions
ConditionsYield
With tetrakis(acetonitrile)copper(I)tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 120℃; for 5h; Mechanism; Sealed tube; Inert atmosphere;98%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

N-ethyl-N-methylbutan-1-amine
66225-40-9

N-ethyl-N-methylbutan-1-amine

N-butyl-N-(difluoromethyl)-N-methylammonium nitrate

N-butyl-N-(difluoromethyl)-N-methylammonium nitrate

Conditions
ConditionsYield
With sodium hydroxide; sodium nitrate In tetrahydrofuran; water at 20℃;97%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

4-biphenylboronic acid 1,2-ethanediol ester
144432-79-1

4-biphenylboronic acid 1,2-ethanediol ester

4-phenyl-α,α-difluorotoluene

4-phenyl-α,α-difluorotoluene

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; hydroquinone In 1,4-dioxane at 110℃; for 48h; Schlenk technique; Inert atmosphere;97%
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; hydroquinone; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 48h; Inert atmosphere; Sealed tube;95%
5-methyl-2-phenyl-1,2,4-triazolidin-3-one

5-methyl-2-phenyl-1,2,4-triazolidin-3-one

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

4,5-dihydro-3-methyl-4-difluoromethyl-1-(2,4-dichlorophenyl)-1,2,4-triazol-5(1H)-one

4,5-dihydro-3-methyl-4-difluoromethyl-1-(2,4-dichlorophenyl)-1,2,4-triazol-5(1H)-one

Conditions
ConditionsYield
Stage #1: 5-methyl-2-phenyl-1,2,4-triazolidin-3-one With chlorine In water; 1,2-dichloro-ethane at 20 - 80℃; for 5.36h; Molecular sieve;
Stage #2: With potassium carbonate In 5,5-dimethyl-1,3-cyclohexadiene; Triethylene glycol dimethyl ether at 140℃; for 4h;
Stage #3: Chlorodifluoromethane In 5,5-dimethyl-1,3-cyclohexadiene; Triethylene glycol dimethyl ether at 185℃; for 0.5h;
96.1%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

4-trifluoromethyl-2,3,5,6-tetrafluorothiophenol
651-84-3

4-trifluoromethyl-2,3,5,6-tetrafluorothiophenol

1-Difluoromethylsulfanyl-2,3,5,6-tetrafluoro-4-trifluoromethyl-benzene

1-Difluoromethylsulfanyl-2,3,5,6-tetrafluoro-4-trifluoromethyl-benzene

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane; water at 45℃; for 3h;96%
1-decylpiperidine
67249-20-1

1-decylpiperidine

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

N-decyl-N-(difluoromethyl)piperidinium chloride

N-decyl-N-(difluoromethyl)piperidinium chloride

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 3.5h;96%
tributyl-amine
102-82-9

tributyl-amine

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

N,N,N-tributyl-N-(difluoromethyl)ammonium chloride

N,N,N-tributyl-N-(difluoromethyl)ammonium chloride

Conditions
ConditionsYield
Stage #1: tributyl-amine With sodium hydroxide In tetrahydrofuran; water at 20℃; for 0.0333333h;
Stage #2: Chlorodifluoromethane In tetrahydrofuran; water
96%
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 3h;92%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

K(1+)*C14H14BO3(1-)

K(1+)*C14H14BO3(1-)

4-phenyl-α,α-difluorotoluene

4-phenyl-α,α-difluorotoluene

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; hydroquinone In 1,4-dioxane at 110℃; for 48h; Schlenk technique; Inert atmosphere;96%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

polytetrafluoroethylene
116-14-3

polytetrafluoroethylene

Conditions
ConditionsYield
With high nickel alloy at 420 - 955℃; for 6.94444E-05h; Temperature;95.2%
In gas Product distribution; Irradiation; dependence on pressure and light intensity;
Pyrolysis;
4-ethoxycarbonylpyrazole
37622-90-5

4-ethoxycarbonylpyrazole

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

ethyl 1-(difluoromethyl)-1H-pyrazole-4-carboxylate
129819-40-5

ethyl 1-(difluoromethyl)-1H-pyrazole-4-carboxylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 2h;95%
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 130 - 140℃; for 3h;41%
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 130 - 140℃; for 3h;41%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

4-difluoromethoxybenzaldehyde
73960-07-3

4-difluoromethoxybenzaldehyde

Conditions
ConditionsYield
Stage #1: 4-hydroxy-benzaldehyde With sodium hydroxide; 18-crown-6 ether In water; isopropyl alcohol for 0.5h;
Stage #2: Chlorodifluoromethane In water; isopropyl alcohol at 65℃; for 5 - 6h;
95%
With sodium hydroxide; sodium dithionite In 1,4-dioxane; water at 65 - 70℃; for 5h;76%
With sodium hydroxide; Tris(3,6-dioxaheptyl)amine In toluene at 105℃; for 1.17h;24%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

phenyl toluenesulfonamide
68-34-8

phenyl toluenesulfonamide

N-(difluoromethyl)-4-methyl-N-phenylbenzenesulfonamide

N-(difluoromethyl)-4-methyl-N-phenylbenzenesulfonamide

Conditions
ConditionsYield
With potassium hydroxide In N,N-dimethyl-formamide at 60 - 70℃;95%
C10H21N(CH3)C2H5

C10H21N(CH3)C2H5

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

N-decyl-N-(difluoromethyl)-N-ethyl-N-methylammonium chloride

N-decyl-N-(difluoromethyl)-N-ethyl-N-methylammonium chloride

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 2h;95%
2-(p-tolyl)-1H-benzimidazole
120-03-6

2-(p-tolyl)-1H-benzimidazole

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

1-(difluoromethyl)-2-(4-methylphenyl)-1H-benzimidazole
1309978-33-3

1-(difluoromethyl)-2-(4-methylphenyl)-1H-benzimidazole

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 90℃;95%
p-nitrobenzene iodide
636-98-6

p-nitrobenzene iodide

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

p-nitrobenzotrifluoride
402-54-0

p-nitrobenzotrifluoride

Conditions
ConditionsYield
With tetrakis(acetonitrile)copper(I)tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 120℃; for 5h; Mechanism; Sealed tube; Inert atmosphere;95%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

1-Naphthylboronic acid
13922-41-3

1-Naphthylboronic acid

1-(difluoromethyl)naphthalene
53731-26-3

1-(difluoromethyl)naphthalene

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; hydroquinone; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 48h; Inert atmosphere; Sealed tube;95%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

3-(tert-butyldimethylsilyloxy)oct-1-yne
60134-93-2

3-(tert-butyldimethylsilyloxy)oct-1-yne

tert-Butyl-[1-(3,3-difluoro-prop-1-ynyl)-hexyloxy]-dimethyl-silane
183996-60-3

tert-Butyl-[1-(3,3-difluoro-prop-1-ynyl)-hexyloxy]-dimethyl-silane

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran 1.) -78 deg C, 30 min, 2.) -78 deg C, 1 h;94%
4-(5-hydroxy-3-trifluoromethyl-pyrazol-1-yl)-benzoic acid ethyl ester
866130-43-0

4-(5-hydroxy-3-trifluoromethyl-pyrazol-1-yl)-benzoic acid ethyl ester

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

4-(5-difluoromethoxy-3-trifluoromethyl-pyrazol-1-yl)-benzoic acid ethyl ester
866130-44-1

4-(5-difluoromethoxy-3-trifluoromethyl-pyrazol-1-yl)-benzoic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at -78 - 100℃; for 12h;94%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

β-naphthaldehyde
66-99-9

β-naphthaldehyde

1,1-difluoro-2-(2-naphthyl)ethene
131581-40-3

1,1-difluoro-2-(2-naphthyl)ethene

Conditions
ConditionsYield
With tetrabutyl-ammonium chloride; triphenylphosphine; methyloxirane In N,N-dimethyl-formamide at 110℃; for 6h; Wittig Olefination; Sealed tube; Molecular sieve; Inert atmosphere;94%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

1-Iodonaphthalene
90-14-2

1-Iodonaphthalene

1-trifluoromethylnaphthalene
26458-04-8

1-trifluoromethylnaphthalene

Conditions
ConditionsYield
With tetrakis(acetonitrile)copper(I)tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 120℃; for 5h; Mechanism; Sealed tube; Inert atmosphere;94%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

K(1+)*C18H22BO3(1-)

K(1+)*C18H22BO3(1-)

4-phenyl-α,α-difluorotoluene

4-phenyl-α,α-difluorotoluene

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; hydroquinone In 1,4-dioxane at 110℃; for 48h; Schlenk technique; Inert atmosphere;94%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

tetrabutylammonium 7-acetylspiro[1,3-benzodioxole-2,4'-tetrahydrothiopyran]-4-olate

tetrabutylammonium 7-acetylspiro[1,3-benzodioxole-2,4'-tetrahydrothiopyran]-4-olate

1-[7-(difluoromethoxy)spiro[1,3-benzodioxole-2,4'-tetrahydrothiopyran]-4-yl]ethanone

1-[7-(difluoromethoxy)spiro[1,3-benzodioxole-2,4'-tetrahydrothiopyran]-4-yl]ethanone

Conditions
ConditionsYield
Stage #1: Chlorodifluoromethane; tetrabutylammonium 7-acetylspiro[1,3-benzodioxole-2,4'-tetrahydrothiopyran]-4-olate In N,N-dimethyl-formamide at 50 - 55℃; Large scale;
Stage #2: With water; sodium hydroxide In N,N-dimethyl-formamide at 45 - 55℃; Large scale;
94%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

C25H23ClN2O3

C25H23ClN2O3

C26H24F2N2O3

C26H24F2N2O3

Conditions
ConditionsYield
With dmap; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; nickel dichloride; zinc In N,N-dimethyl acetamide at 60℃; for 12h; Molecular sieve;94%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

C11H6BrF3

C11H6BrF3

2-(3-bromophenyl)-3-((difluoromethyl)selanyl)-4-(trifluoromethyl)selenophene

2-(3-bromophenyl)-3-((difluoromethyl)selanyl)-4-(trifluoromethyl)selenophene

Conditions
ConditionsYield
With selenium; water; potassium carbonate In N,N-dimethyl-formamide at 120℃; for 10h; Schlenk technique; Inert atmosphere; regioselective reaction;94%

75-45-6Upstream product

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