189813-45-4

Basic information

• Product Name: Benzeneacetic acid, 2-(chloroMethyl)-alpha-(MethoxyiMino)-, Methyl ester,(alphaE)-
• Synonyms: Benzeneacetic acid, 2-(chloroMethyl)-alpha-(MethoxyiMino)-, Methyl ester,(alphaE)-
• CAS NO: 189813-45-4
• Molecular Formula: C₁₁H₁₂ClNO₃
• Molecular Weight: 241.67088
• Mol File: 189813-45-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzeneacetic acid, 2-(chloroMethyl)-alpha-(MethoxyiMino)-, Methyl ester,(alphaE)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 2-(chloroMethyl)-alpha-(MethoxyiMino)-, Methyl ester,(alphaE)-(189813-45-4)
• EPA Substance Registry System: Benzeneacetic acid, 2-(chloroMethyl)-alpha-(MethoxyiMino)-, Methyl ester,(alphaE)-(189813-45-4)

Safety Data

• Hazardous Substances Data: 189813-45-4(Hazardous Substances Data)

Upstream product

• 4385-35-7 isochroman-3-one 
• 67-56-1 methanol 
• 149728-96-1 isochroman-3,4-dione 4-(O-methyl-oxime) 
• 130490-95-8 methyl [2-(chloromethyl)benzoyl]formate 
• 593-56-6 N-methoxylamine hydrochloride 
• 847027-68-3 methyl (E/Z)-2-(2-chloromethylphenyl)-2-methoximinoacetate 

Downstream Products

• 167374-38-1 methyl 2-(2,5-dimethylphenoxymethyl)-α-methoxyiminophenylacetate 
• 143390-89-0 methyl (E)-2-methoxyimino-2-[2-(o-tolyloxymethyl)phenyl]acetate 
• 248593-16-0 orysastrobin 
• 43121-43-3 trifloxystrobin 

Relevant articles and documents

Trifloxystrobin synthesizing method

The invention discloses a trifloxystrobin synthesizing method, and relates to the preparation of trifloxystrobin in organic chemicals. The trifloxystrobin synthesizing method comprises the following steps of using hydroxy methyl phenylacetic acid lactone as raw material to react with TBN (tributyrin), absolute methanol and sodium methoxide to obtain (E)-3-keto-4-(isonitroso)isochroman; using the (E)-3-keto-4-(isonitroso)isochroman to react with acetone and potassium carbonate, and dropwise adding the acetone solution of dimethyl sulfate after a large amount of bright yellow solids occurs, so as to obtain (E)-3-keto-4-(methoxyimino)isochroman; dissolving the obtained (E)-3-ketone-4-(methoxyimino)isochroman by methanol, and dropwise adding thionyl chloride under the low-temperature condition to prepare (E)-2-chlororated methyl-alpha-methoxyimino methyl phenylacetate; after the catalysis of 3-(trifluoromethyl)acetophenone and hydroxylamine hydrochloride, using absolute ethyl alcohol and as solvent to obtain light earthy yellow solid (E)-3-(trifluoromethyl)acetophenone oxime; enabling the (E)-2-bromomethyl-alpha-methoxyimino methyl phenylacetate and the (E)- 3-(trifluoromethyl)acetophenone oxime to react in a DMF (dimethyl formamide) solution of the potassium hydroxide, so as to obtain the white solid of trifloxystrobin.

METHOD FOR PRODUCING 2-HALOGENOMETHYLPHENYL ACETIC ACID DERIVATIVES

The present invention relates to a process for producing 2-halogenomethylphenyl acetic acid derivatives.

IMPROVED PROCESS FOR PREPARING O-CHLOROMETHYLPHENYLGLYOXYLIC ESTERS, IMPROVED PROCESS FOR PREPARING (E)-2-(2-CHLOROMETHYLPHENYL)-2-ALKOXIMINOACETIC ESTERS, AND NOVEL INTERMEDIATES FOR THEIR PREPARATION

An improved process for preparing o-chloromethylphenylglyoxylic esters of the formula (I) which comprises converting a compound of the formula (II) by reaction with magnesium into the corresponding Grignard reagent which is then reacted with a compound of the formula (III) to give the compound of the formula (IV) which is then cleaved by reaction with a chloroformic ester of the formula ClCOOR4 or by reaction with phosgene to give the compound of the formula (I), followed by the isolation of the compound of the formula (I), and also an improved process for preparing (E)-2-(2-chloromethylphenyl)- 2-alkoximinoacetic esters of the formula (VII) and intermediates for their preparation.