189818-30-2

Basic information

• Product Name: C₃₉H₄₀N₄O₄
• Synonyms: C₃₉H₄₀N₄O₄
• CAS NO: 189818-30-2
• Molecular Weight: 628.771
• Mol File: 189818-30-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₉H₄₀N₄O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₉H₄₀N₄O₄(189818-30-2)
• EPA Substance Registry System: C₃₉H₄₀N₄O₄(189818-30-2)

Safety Data

• Hazardous Substances Data: 189818-30-2(Hazardous Substances Data)

Upstream product

• 28188-41-2 m-(bromomethyl)benzonitrile 
• 167828-27-5 (4R,5R,6R)-tetrahydro-5-O-[(2-methoxyethoxy)methyl]-4-(2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone 
• 152929-72-1 [(1R,2S,3R)-3-Azido-1-benzyl-2-(2-methoxy-ethoxymethoxy)-5-phenyl-pentyl]-carbamic acid benzyl ester 
• 152929-71-0 ((1R,2S,3R)-3-Azido-1-benzyl-2-hydroxy-5-phenyl-pentyl)-carbamic acid benzyl ester 
• 120452-49-5 N-methoxy-N-methyl-(R)-N²-Cbz-phenylalaninamide 
• 41518-17-6 C₂₂H₂₅NO₆ 
• 2448-45-5 Cbz-D-Phe 
• 188978-27-0 Methanesulfonic acid 1-((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-allyl ester 
• 152929-76-5 (2R,3R,4R)-3-(2-Methoxy-ethoxymethoxy)-1,6-diphenyl-hexane-2,4-diamine 
• 152929-75-4 ((E)-(R)-1-Benzyl-5-phenyl-pent-2-enyl)-carbamic acid benzyl ester 
• 188978-26-9 ((R)-1-Benzyl-2-hydroxy-but-3-enyl)-carbamic acid benzyl ester 
• 152929-68-5 ((R)-1-Benzyl-2-oxo-but-3-enyl)-carbamic acid benzyl ester 

Downstream Products

• 167824-09-1 (4R,5R,6R)-tetrahydro-1,3-bis[(3-cyanophenyl)methyl]-5-hydroxy-4-(2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone 

Relevant articles and documents

Design, synthesis, and evaluation of tetrahydropyrimidinones as an example of a general approach to nonpeptide HIV protease inhibitors

Re-examination of the design of the cyclic urea class of HIV protease (HIVPR) inhibitors suggests a general approach to designing novel nonpeptide cyclic HIVPR inhibitors. This process involves the inversion of the stereochemical centers of the core transition-state isostere of the linear HIVPR inhibitors and cyclization of the resulting core using an appropriate cyclizing reagent. As an example, this process is applied to the diamino alcohol class of HIVPR inhibitors to give tetrahydropyrimidinones. Conformational analysis of the tetrahydropyrimidinones and modeling of its interaction with the active site of HIVPR suggested modifications which led to very potent inhibitors of HIVPR (24 with a K(i) = 0.018 nM). The X-ray crystallographic structure of the complex of 24 with HIVPR confirms the analysis and modeling predictions. The example reported in this study and other examples that are cited indicate that this process may be generally applicable to other linear inhibitors.