189876-47-9

Upstream product

• 883-44-3 N-(3-hydroxypropyl)phthalimide 
• 85-44-9 phthalic anhydride 
• 828-27-3 4-Trifluoromethoxyphenol 
• 88597-06-2 3-(phthalimido)propyl-p-toluenesulfonate 

Downstream Products

• 1332302-36-9 N-methyl-3-(4-(3-(4-(trifluoromethoxy)phenoxy)propylamino)pyrimidin-2-ylamino)benzamide 
• 1332302-37-0 2-chloro-N-(3-(4-(trifluoromethoxy)phenoxy)propyl)pyrimidin-4-amine 
• 189876-53-7 3-(4-(trifluoromethoxy)phenoxy)propan-1-amine 

Relevant academic research and scientific papers

ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN

The present invention provides compounds that are inhibitors of voltage-gated sodium channels (Nav), in particular Nav 1.7, and are therefore useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorders. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.