189894-79-9Relevant academic research and scientific papers
Synthesis and evaluation of novel phosphate ester analogs as neutral sphingomyelinase inhibitors
Imagawa, Hiroshi,Oda, Masataka,Takemoto, Takayuki,Yamauchi, Rieko,Yoshikawa, Tomomi,Yamamoto, Hirofumi,Nishizawa, Mugio,Takahashi, Hironobu,Hashimoto, Manabu,Yabiku, Kenta,Nagahama, Masahiro,Sakurai, Jun
supporting information; experimental part, p. 3868 - 3871 (2010/09/03)
A novel sphingomyelin inhibitor RY221B-a, which contains a bipyridyl moiety as a metal coordination site was designed based upon the mechanism of phosphate ester hydrolysis. RY221B-a was synthesized from N-Boc-sphingosine in three steps via selective etherification using stannyl acetal. Synthesized RY221B-a exhibited relatively-strong inhibitory activity against Bc-SMase (IC 50 = 1.2 μM).
SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR
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Page/Page column 14, (2009/12/27)
An object of the invention is to provide a novel sphingosine compound with an inhibitory activity against sphingomyelinase, and a method for producing the sphingosine compound. The novel sphingosine compound or a salt thereof according to the invention is represented by Formula (1): wherein one of R1 and R2 is hydrogen, and the other is a group represented by Formula (G): wherein n is 0 or 1; and R3 is hydrogen, C1-23 alkyl, C3-8 cycloalkyl, C2-6 alkenyl, C1-6 alkoxy, C3-8 cycloalkyloxy, phenyl, or furil.
Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells
Park, Jin,Li, Qian,Chang, Young-Tae,Kim, Tae Sung
, p. 2589 - 2595 (2007/10/03)
Allergic diseases are hypersensitivity disorders associated with the production of specific immunoglobulin E (IgE) to environmental allergens. Interleukin (IL)-4, produced primarily by CD4+ T cells, is an important stimulus for the switch of th
The synthesis and biological characterization of a ceramide library
Chang, Young-Tae,Choi, Jaehwa,Ding, Sheng,Prieschl, Eva E.,Baumruker, Thomas,Lee, Jae-Mok,Chung, Sung-Kee,Schultz, Peter G.
, p. 1856 - 1857 (2007/10/03)
A facile synthesis of a combinatorial ceramide library and their activities in the NF-κB pathway and in apoptosis induction/prevention were demonstrated. A novel NF-κB activating molecule was discovered among ceramide containing β-galactose, and the structural requirements of ceramides for apoptosis induction was elucidated. Copyright
