189894-79-9Relevant articles and documents
Synthesis and evaluation of novel phosphate ester analogs as neutral sphingomyelinase inhibitors
Imagawa, Hiroshi,Oda, Masataka,Takemoto, Takayuki,Yamauchi, Rieko,Yoshikawa, Tomomi,Yamamoto, Hirofumi,Nishizawa, Mugio,Takahashi, Hironobu,Hashimoto, Manabu,Yabiku, Kenta,Nagahama, Masahiro,Sakurai, Jun
supporting information; experimental part, p. 3868 - 3871 (2010/09/03)
A novel sphingomyelin inhibitor RY221B-a, which contains a bipyridyl moiety as a metal coordination site was designed based upon the mechanism of phosphate ester hydrolysis. RY221B-a was synthesized from N-Boc-sphingosine in three steps via selective etherification using stannyl acetal. Synthesized RY221B-a exhibited relatively-strong inhibitory activity against Bc-SMase (IC 50 = 1.2 μM).
Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells
Park, Jin,Li, Qian,Chang, Young-Tae,Kim, Tae Sung
, p. 2589 - 2595 (2007/10/03)
Allergic diseases are hypersensitivity disorders associated with the production of specific immunoglobulin E (IgE) to environmental allergens. Interleukin (IL)-4, produced primarily by CD4+ T cells, is an important stimulus for the switch of th