189894-90-4Relevant academic research and scientific papers
Pyridazine and its related compounds. Part 36. Synthesis and antimicrobial activity of some novel pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine derivatives
Deeb, Ali,Mahgoub, Sebaey
, p. 4559 - 4569 (2016/02/20)
Novel derivatives of pyrimidothienopyridazine were designed and synthesized through a versatile method. Some of the target compounds bearing the sulfonamide group were evaluated for their antimicrobial activity against representative Gram-positive bacteria, Gram-negative bacteria, and fungi by applying the agar plate diffusion technique. The results showed that derivatives 11a have promising inhibitory activity against Gram-positive bacteria, and derivatives 11b and 11e have also potent inhibition against fungi. Rest of the compounds showed moderate to low activity against the examined micro-organisms.
Synthesis and reactions of some new heterocyclic compounds containing thieno[2,3-c] pyridazine moiety
Radwan
, p. 153 - 169 (2007/10/03)
Saponification of ethyl 3-amino-4,5-diphenylthieno[2,3-c]pyridazine-2-carboxyate (1) with alcoholic sodium hydroxide, followed by acidification, afforded the corresponding acid 2. Also, reaction of 1 with ethanolamine and formamide, respectively, gave compounds 5 and 6. Compound 2 reacts with orthophosphoric acid under different conditions to give some new thieno[2,3-c] pyridazine derivatives 3 and 4, which were subjected to reactions to produce compounds 7-18. Furtheremore, compounds 5 and 6 were used to synthesize some substituted pyrimido[4′,5′:4,5)-thieno[2,3-c]pyridazine derivatives 21-30.
Synthesis of New Pyridazino[4′,3′:4,5]-thieno[3,2-d]-1,2,3-triazine and Pyrimido [4′,5′:4,5]thieno[2,3-c]pyridazine Derivatives
Quintela,Veiga,Alvarez-Sarandes,Gonzalez,Peinador
, p. 1037 - 1043 (2007/10/03)
8,9-Diphenylpyridazino[4′,3′:4,5]thieno[3,2-d]-1,2,3-triazin- 4(3H)-one (2), 3-substituted 8,9-diphenylpyridazino[4′,3′:4,5]thieno[3,2-d]-1,2,3-triazin-4(3H)- ones (3a-c), 3,4-diphenylpyrimido-[4′,5′:4,5]thieno[2,3-c]pyridazin-8(7H)-one (4), 8-chloro-3,4-diphenylpyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine (5), 8-substituted 3,4-diphenylpyrimido[4′,5′:4,5]thieno[2,3-c]pyridazines (6a-h) and 7-substituted 3,4-diphenylpyrimido[4′,5′:4,5]thieno[2,3-c]pyridazin-8(7H)-ones(7a- c) were synthesized from 5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxamide (1).
