1899-99-6

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-methoxy-6-methyl-5-nitropyrimidine is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of various medicinal compounds. Its unique structure allows it to be a key component in the creation of drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-4-methoxy-6-methyl-5-nitropyrimidine serves as a building block for the manufacturing of various pesticides. Its incorporation into these products enhances their effectiveness in controlling pests and diseases, thereby contributing to improved crop protection and yield.
Used in Organic Chemistry Research:
2-Chloro-4-methoxy-6-methyl-5-nitropyrimidine is also utilized in organic chemistry research as a valuable compound for exploring new reactions and syntheses. Its presence in various chemical processes aids scientists in understanding and advancing the field of organic chemistry, potentially leading to the discovery of new compounds and applications.

InChI:InChI=1/C6H6ClN3O3/c1-3-4(10(11)12)5(13-2)9-6(7)8-3/h1-2H3

Upstream product

• 626-48-2 2,4-dihydroxy-6-methylpyrimidine 
• 16632-21-6 6-methyl-5-nitropyrimidine-2,4-diol 
• 13162-26-0 2,4-dichloro-6-methyl-5-nitropyrimidine 
• 124-41-4 sodium methylate 

Downstream Products

• 1067228-98-1 C₁₅H₁₁F₆N₃O₄ 
• 1067228-99-2 C₁₄H₁₄ClN₃O₅ 
• 600178-96-9 2-(2-difluoromethoxy-6-methoxy-phenyl)-5-dipropylamino-6-methyl-3H-pyrimidin-4-one 
• 391936-44-0 5-dipropylamino-6-ethyl-2-(2-methoxy-4,6-dimethyl-phenyl)-3H-pyrimidin-4-one 
• 360577-04-4 [2-(2-methoxy-4,6-dimethylphenyl)-4-methoxy-6-ethyl pyrimidin-5-yl]dipropylamine 
• 391936-61-1 5-dipropylamino-2-(2-methoxy-4,6-dimethyl-phenyl)-6-methyl-3H-pyrimidin-4-one 
• 360576-57-4 [4-methoxy-2-(2-methoxy-4,6-dimethyl-phenyl)-6-methyl-pyrimidin-5-yl]-dipropylamine 

Relevant academic research and scientific papers

Synthetic Strategies toward the Synthesis of 2,4-Dimethoxypyrrolopyrimidine

Two approaches to prepare 2,4-dimethoxypyrrolopyrimidine (1) are described. 2,4-Dimethoxy-6-methyl-5-nitropyrimidine (2) was converted to 6-(cyanomethyl)-2,4-dimethoxy-5-nitropyrimidine (6) in two steps.Subsequent catalytic hydrogenation of 6 produced 1.In a second approach, 2 was formylated, giving rise to 6--2,4-dimethoxy-5-nitropyrimidine (7).Hydrogenation of 7 resulted in the formation of 1.Reduction of 2 provided 5-amino-2,4-dimethoxy-6-methylpyrimidine (10).Reaction of compound 10 with triethyl orthoformate produced 2,4-dimethoxy-5--6-methylpyrimidine (11).Reaction of 11 with lithium diisopropylamide gave 2,4-dimethoxy-5-isocyano-6-methylpyrimidine (12).

CYCLIC COMPOUNDS

There is provided a CRF receptor antagonist comprising a compound of the formula (I): A-W-Ar wherein, A is a group represented by the formula (A1) or (A2) (wherein, ring Aa is a 5-or 6-membered ring which may be further substituted; ring Ab is a 5-or 6-membered ring which may be further substituted; ring Ac is a 5- or 6-membered ring which may be substituted; R1 is optionally substituted alkyl, substituted amino, substituted hydroxy, etc.; X is carbonyl, -O-, -S-, etc.; Y1, Y2 and Q are independently optionally substituted carbon or nitrogen; … is a single or double bond); W is a bond, optionally substituted methylene, optionally substituted imino, -O-, -S-, etc.; Ar is optionally substituted aryl or optionally substituted heteroaryl; or a salt thereof or a prodrug thereof.

2-Aryl-3,6-dialkyl-5-dialkylaminopyrimidin-4-ones as novel CRF-1 receptor antagonists

The discovery, synthesis and structure-activity studies of a novel series of 2-arylpyrimidin-4-ones as CRF-1 receptor antagonists is described. These compounds are structurally simple and display appropriate physical properties for CNS agents