18994-70-2Relevant academic research and scientific papers
Synthesis of ω-carbamoyloxyalkylimidazolium salts for evaluation as protective agents against acetylcholinesterase intoxication by soman
Sundberg, Richard J.,Van Nguyen, Phuoc
, p. 123 - 136 (2007/10/03)
A series of N-methyl and N,N-dimethylcarbamoyloxyalkylimidazolium salts has been prepared. The carbamoyloxyalkyl groups are varied from methyl through propyl at the 1,2 or 4 positions of the imidazolium ring. The 2- and 4-substituted series show modest activity as inhibitors of acetylcholinesterase. Several of the compounds show prophylactic activity against soman toxicity but there is no correlation between AChE inhibitory activity and the prophylatic effect, suggesting that reversible carbamoylation is not the basis for the prophylactic effect.
