189945-43-5Relevant academic research and scientific papers
Efficient macrocyclization by a novel oxy-oxonia-cope reaction: Synthesis and olfactory properties of new macrocyclic musks
Zou, Yue,Mouhib, Halima,Stahl, Wolfgang,Goeke, Andreas,Wang, Quanrui,Kraft, Philip
supporting information; experimental part, p. 7010 - 7015 (2012/07/03)
Musk made to odor: A new oxy-oxonia-Cope macrocyclization to (3Z)-configured cycloalk-3-en-1-yl formates is reported, which is useful in the synthesis of unsaturated and saturated macrocyclic ketones (see scheme). The synthesized structures provide new insight into the structure-odor correlation of musks, making it likely for macrocyclic and linear alicyclic musks to address the same olfactory receptors.
Total synthesis of asimicin via highly stereoselective [3 + 2] annulation reactions of substituted allylsilanes
Tinsley, Jennifer M.,Roush, William R.
, p. 10818 - 10819 (2007/10/03)
A highly stereoselective total synthesis of (+)-asimicin (1) is reported. The synthesis features two chelate-controlled [3 + 2] annulation reactions - one of which (e.g., 2 + 3) constitutes a key, convergent fragment assembly step - that establish all of the stereochemistry of the bis-tetrahydrofuran unit of the natural product. Copyright
