863604-34-6Relevant academic research and scientific papers
Total synthesis of asimicin via highly stereoselective [3 + 2] annulation reactions of substituted allylsilanes
Tinsley, Jennifer M.,Roush, William R.
, p. 10818 - 10819 (2007/10/03)
A highly stereoselective total synthesis of (+)-asimicin (1) is reported. The synthesis features two chelate-controlled [3 + 2] annulation reactions - one of which (e.g., 2 + 3) constitutes a key, convergent fragment assembly step - that establish all of the stereochemistry of the bis-tetrahydrofuran unit of the natural product. Copyright
