189949-21-1

Basic information

• Product Name: (S)-1-(1-phenylsulfonylindol-2-yl)propan-2-ol
• Synonyms: (S)-1-(1-phenylsulfonylindol-2-yl)propan-2-ol
• CAS NO: 189949-21-1
• Molecular Weight: 315.393
• Mol File: 189949-21-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-(1-phenylsulfonylindol-2-yl)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(1-phenylsulfonylindol-2-yl)propan-2-ol(189949-21-1)
• EPA Substance Registry System: (S)-1-(1-phenylsulfonylindol-2-yl)propan-2-ol(189949-21-1)

Safety Data

• Hazardous Substances Data: 189949-21-1(Hazardous Substances Data)

Upstream product

• 40899-71-6 1-benzenesulfonylindole 
• 174953-30-1 (S)-(+)-4-methyl-2,2-dioxo-1,3,2-dioxathiolane 

Downstream Products

• 188200-22-8 C₅₃H₇₀N₅O₁₁PSi₂ 

Relevant articles and documents

Indolyl-oxazaphosphorine Precursors for Stereoselective Synthesis of Phosphite Triesters and Dithymidinyl Phosphorothioates

Several novel chiral indolyl-oxazaphosphorines 7 were synthesized, and their potential as precursors to chiral phosphorothioates was evaluated. Reaction of 7 with a thymidine derivative gave phosphite triester 8 with a large degree of stereoselectivity. Sulfurization with Beaucage's reagent provided phosphorothioate triesters 9. The chiral auxiliary 9b containing a cyano group could be easily removed with aqueous ammonia to form dithymidinyl phosphorothioate in more than 97% diastereomeric excess. The chiral indolyl-oxazaphosphorines 7 are a new class of precursors for stereoselective synthesis of phosphorothioates.