189955-79-1Relevant articles and documents
Synthetic method for firocoxib important intermediate
-
Paragraph 0044; 0045; 0046; 0047; 0048; 0049-0064, (2019/01/14)
The invention relates to a synthetic method for a firocoxib important intermediate. P-methyl-iso-butyryl benzene is taken as an initial raw material and a one-pot method is adopted for firstly generating a bromide intermediate in a NBS (N-bromosuccinimide
Firocoxib preparation method
-
Paragraph 0014; 0015, (2017/03/14)
The invention discloses a firocoxib preparation method and relates to the technical field of chemical synthesis, in particular to a novel method for synthesizing firocoxib. The novel method for synthesizing the firocoxib includes subjecting thioanisole serving as a raw material to acylation reaction, bromination reaction, oxidizing reaction, esterification reaction and cyclization reaction sequentially so as to obtain the firocoxib. Compared with a traditional technology, the novel method for synthesizing the firocoxib has the advantages that an aftertreatment process is simple without column chromatography separation, and the method is high in yield, low in cost and suitable for industrial production.
(Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
-
, (2008/06/13)
The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.