189955-79-1

Upstream product

• 53207-58-2 2-methyl-1-(4-(methylthio)phenyl)-propan-1-one 
• 100-68-5 methyl-phenyl-thioether 
• 88324-55-4 2-bromo-2-methyl-1-[4-(methylsulfanyl)phenyl]propan-1-one 
• 53207-59-3 2-methyl-1-[4-(methylsulfonyl)phenyl]propan-1-one 

Downstream Products

• 246869-15-8 2-cyclopropylmethoxyacetic acid [1,1-dimethyl-2-(4-methanesulfonylphenyl)-2-oxoethyl]ester 
• 180048-73-1 2-hydroxy-2-methyl-1-(4-(methylsulfonyl)-phenyl)propan-1-one 
• 190966-58-6 (1R,2S)-1-(1-Ethoxy-ethoxy)-1-(4-methanesulfonyl-phenyl)-2-methyl-butan-2-ol 
• 189956-10-3 (S)-2-[(R)-(1-Ethoxy-ethoxy)-(4-methanesulfonyl-phenyl)-methyl]-2-methyl-oxirane 
• 189956-13-6 (S)-2-hydroxy-2-methyl-1-[4-(methylsulfonyl)phenyl]butan-1-one 
• 189956-09-0 (R)-(4-Methanesulfonyl-phenyl)-((S)-2-methyl-oxiranyl)-methanol 
• 189956-08-9 (S)-2-Methyl-1-(4-methylsulfonylphenyl)-prop-2-en-1-ol 
• 455878-44-1 (S)-1-ethyl-1-methyl-2-[(4-methylsulfonyl)phenyl]-2-oxoethyl 2-(1-methylethoxy)acetate 
• 189954-93-6 (S)-5-ethyl-5-methyl-3-(1-methylethoxy)-4-[(4-methylsulfonyl)phenyl]-3-oxolen-2-one 
• 516453-68-2 2-methyl-1-[4-(methylsulfonyl)phenyl]prop-2-en-1-one 

Relevant academic research and scientific papers

Synthetic method for firocoxib important intermediate

The invention relates to a synthetic method for a firocoxib important intermediate. P-methyl-iso-butyryl benzene is taken as an initial raw material and a one-pot method is adopted for firstly generating a bromide intermediate in a NBS (N-bromosuccinimide

A PROCESS FOR THE PREPARATION OF FIROCOXIB

The present invention provides an improved process for preparation of Firocoxib of Formula I. Further, the present invention relates to novel process for the preparation of crystalline polymorphic form B of Firocoxib of Formula I.

Firocoxib preparation method

The invention discloses a firocoxib preparation method and relates to the technical field of chemical synthesis, in particular to a novel method for synthesizing firocoxib. The novel method for synthesizing the firocoxib includes subjecting thioanisole serving as a raw material to acylation reaction, bromination reaction, oxidizing reaction, esterification reaction and cyclization reaction sequentially so as to obtain the firocoxib. Compared with a traditional technology, the novel method for synthesizing the firocoxib has the advantages that an aftertreatment process is simple without column chromatography separation, and the method is high in yield, low in cost and suitable for industrial production.

METAL FREE BLEACHING COMPOSITION

The present invention relates to the use of a composition comprising specific a-amino- ketones, H2O2, a H2O2 precursor or a peracid and optionally an activator as a bleaching mixture for textile materials or dis

(Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

ALKYLATED STYRENES AS PRODRUGS TO COX-2 INHIBITORS

The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).

(Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors

The invention encompasses the novel compound of Formula A that is useful in the treatment of cyclooxygenase-2 mediated diseases. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula A.

Alkylated styrenes as prodrugs to COX-2 inhibitors

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

3,4-diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to COX-2 inhibitors

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.