53207-59-3

Usage

Uses

Used in Organic Synthesis:
2-Methyl-1-[4-(Methylsulfonyl)phenyl]-1-propanone is used as a synthetic intermediate for the production of a wide range of organic compounds. Its unique chemical structure allows it to be a versatile starting material in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Methyl-1-[4-(Methylsulfonyl)phenyl]-1-propanone is used as a key component in the development of new drugs. Its incorporation into drug molecules can potentially enhance their therapeutic properties, such as improving their efficacy, selectivity, and bioavailability.
Used in Agrochemical Industry:
2-Methyl-1-[4-(Methylsulfonyl)phenyl]-1-propanone also finds application in the agrochemical industry, where it is used as a building block for the synthesis of various agrochemicals, such as pesticides and herbicides. Its use in this industry can contribute to the development of more effective and environmentally friendly products.
Used in Specialty Chemicals:
In the specialty chemicals sector, 2-Methyl-1-[4-(Methylsulfonyl)phenyl]-1-propanone is employed as a crucial intermediate for the synthesis of various specialty chemicals, including dyes, fragrances, and additives. Its unique properties enable the creation of novel products with specific applications in various industries.

Upstream product

• 99059-63-9 1-(4-iodophenyl)-2-methyl-1-propanone 
• 67-68-5 dimethyl sulfoxide 
• 49660-93-7 4'-bromoisobutyrophenone 
• 20277-69-4 sodium methansulfinate 
• 10342-83-3 4'-Bromopropiophenone 
• 67-56-1 methanol 
• 10297-73-1 4-(methanesulfonyl)acetophenone 
• 100-68-5 methyl-phenyl-thioether 
• 53207-58-2 2-methyl-1-(4-(methylthio)phenyl)-propan-1-one 

Downstream Products

• 189955-89-3 3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2(5H)-one 
• 189954-96-9 3-(Cyclopropylmethoxy)-5.5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one 
• 180048-73-1 2-hydroxy-2-methyl-1-(4-(methylsulfonyl)-phenyl)propan-1-one 
• 189955-79-1 2-bromo-2-methyl-1-[4-(methylsulfonyl)phenyl]propan-1-one 

Relevant academic research and scientific papers

Synthesis and biological properties of aryl methyl sulfones

A novel group of aryl methyl sulfones based on nonsteroidal anti-inflammatory compounds exhibiting a methyl sulfone instead of the acetic or propionic acid group was designed, synthesized and evaluated in vitro for inhibition against the human cyclooxygenase of COX-1 and COX-2 isoenzymes and in vivo for anti-inflammatory activity using the carrageenan induced rat paw edema model in rats. Also, in vitro chemosensitivity and in vivo analgesic and intestinal side effects were determined for defining the therapeutic and safety profile. Molecular modeling assisted the design of compounds and the interpretation of the experimental results. Biological assay results showed that methyl sulfone compounds 2 and 7 were the most potent COX inhibitors of this series and best than the corresponding carboxylic acids (methyl sulfone 2: IC50 COX-1 = 0.04 and COX-2 = 0.10 μM, and naproxen: IC50 COX-1 = 11.3 and COX-2 = 3.36 μM). Interestingly, the inhibitory activity of compound 2 represents a significant improvement compared to that of the parent carboxylic compound, naproxen. Further support to the results were gained by the docking studies which suggested the ability of compound 2 and 7 to bind into COX enzyme with low binding free energies. The improvement of the activity of some sulfones compared to the carboxylic analogues would be performed through a change of the binding mode or mechanism compared to the standard binding mode displayed by ibuprofen, as disclosed by molecular modeling studies. So, this study paves the way for further attention in investigating the participation of these new compounds in the pain inhibitory mechanisms. The most promising compounds 2 and 7 possess a therapeutical profile that enables their chemical scaffolds to be utilized for development of new NSAIDs.

Synthesis methods of firocoxib and firocoxib intermediate

The invention relates to the field of medicine synthesis and provides synthesis methods of firocoxib and a firocoxib intermediate. The synthesis method of the firocoxib intermediate takes 4'-bromopropiophenone as a starting raw material and a condition th

Methylation of C(sp3)-H/C(sp2)-H bonds with methanol catalyzed by cobalt system

A highly efficient Co-based catalytic system, composed of a commercially available Co salt, a tetradentate phosphine ligand P-(CH2CH2PPh2)3(PP3), and a base (denoted as [Co]/PP3/base), is developed for the methylation of C(sp3)-H and C(sp2)-H bonds using methanol as a methylating reagent. The Co(BF4)2.6H2O/PP3/K2CO3 catalytic system showed high catalytic activity for the methylation of C-H bonds in aryl alkyl ketones, aryl acetonitriles, and indoles, with wide substrate scope and good functional group tolerance, and methylsubstituted products were obtained in good to excellent yields at 100 °C. This cheap, readily available, and highly efficient Co-based catalytic system may have promising applications in methylation reaction using methanol.

Process for making phenyl heterocycles useful as COX-2 inhibitors

The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.