189955-91-7Relevant academic research and scientific papers
An aldol approach to the enantioselective synthesis of (-)-oseltamivir phosphate
Trajkovic, Milos,Ferjancic, Zorana,Saicic, Radomir N.
supporting information; experimental part, p. 6927 - 6929 (2011/11/05)
A formal asymmetric synthesis of the antiviral agent (-)-oseltamivir phosphate is achieved using two aldol reactions as key steps.
Azide-free synthesis of oseltamivir from L-methionine
Oshitari, Tetsuta,Mandai, Tadakatsu
scheme or table, p. 787 - 789 (2009/07/25)
Highly enantioselective synthesis of oseltamivir has been achieved starting from L-methionine, in which Staudinger reaction is utilized for the alignment of three contiguous chiral centers of oseltamivir. The present method would lead to an alternative sy
BENZIMIDAZOLE DERIVATIVES
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, (2008/06/13)
This invention relates to the compounds represented by a general formula [I]: ???[in which A1 and A2 represent optionally fluorine-substituted methine or the like; B represents halogen, cyano, lower alkyl or the like; D represents optionally substituted heterocyclic group or the like; and G represents C3-C20 aliphatic group such as alicyclic group]. These compounds inhibit nociceptin activities due to their high affinity to nociceptin receptor, and are useful as analgesic, antiobestic, corebral function improver, drugs for treatment of alzheimer's disease and dementia, remedies for schizophrenia and neurodegenerative diseases, antidepressant, remedies for diabetes insipidus, polyuria, hypotension and so on.
SAR in the alkoxy lactone series: The discovery of DFP, a potent and orally active COX-2 inhibitor
Leblanc,Roy,Boyce,Brideau,Chan,Charleson,Gordon,Grimm,Guay,Leger,Li,Riendeau,Visco,Wang,Webb,Xu,Prasit
, p. 2207 - 2212 (2007/10/03)
Extensive SAR has been established in the alkoxy lactone series and this has lead to the discovery of DFP (5,5-dimethyl-3-(2-propoxy)-4- methanesulfonylphenyl)-2(5H)-furanone), a potent COX-2 inhibitor exhibiting in vivo efficacy in all models studied.
