3926-62-3 Usage
description
Sodium chloroacetate is a white colored powdered solid. It is soluble in water. It may be toxic ingestion or inhalation. It is used as a contact herbicide and a component in other herbicides, an intermediate in the production of carboxymethyl-cellulose, and other synthetic organic chemicals.In one study systemic effects to Sprague-Dawley rats (M/F, numbers per group not indicated) given single doses of sodium chloroacetate at 94, 282, or 470 mg/kg bw demonstrated increased sodium concentration in urine, increased potassium concentration in plasma, and reduced glutathione level in the liver at the highest dose; 2/3 of males died within 24 hours of treatment in the middle and high dose groups.
Stability and Reactivity:
Sodium chloroacetate is?stable at normal temperatures and ?pressures. Incompatible with oxidizing agents, reducing ?agents.
HUMAN USE AND EXPERIENCE
There are a number of case studies of the parent compound, ?monochloroacetic acid (MCA), involving corrosion of skin and ?eyes and fatalities related to skin absorption of toxicologically ?significant amounts of MCA and a health-based target ?concentration of 0.1 mg/L was calculated for MCA in drinking ?water although Health Canada and Environment Canada have ?categorized MCA as not entering the environment at levels that ?may be hazardous to human health. There are, however, no ?similar data or epidemiological reports for sodium ?chloroacetate.
Metabolism/Pharmacokinetics
After absorption, monochloroacetic acid (parent compound ?CAS 79-11-8) is converted to thiodiacetic acid and glycolic acid ?and is accumulated in the liver and kidneys of rats.Metabolism of sodium monochloroacetate is expected to have a ?similar pharmacokinetic profile.
Chemical Properties
Sodium chloroacetate is a white crystalline powder. It is soluble in water. It may be toxic ingestion or inhalation.Sodium chloroacetate is a reactive and toxic material, so it is hydrolyzed to glycolic acid nearly quantitatively at the end of the production cycle. Chloroacetic acid always contains traces of dichloroacetic acid, a toxic and unreactive material that appears on the California Prop.65 list.
Uses
Different sources of media describe the Uses of 3926-62-3 differently. You can refer to the following data:
1. Sodium chloroacetate is the sodium salt of chloroacetic acid. It is used to prepare weed killers, dyes, vitamins and active pharmaceutical ingredients. It is also used as an odor agent, surface active agent and viscosity adjustor. Sodium dihydroxyethyltallow glycinate is the condensation product of dihydroxyethyl tallow amine and sodiumchloroacetate.It is used as a thickeningagent and asurfactant.
2. Sodium chloroacetate is used to prepare dyes and active pharmaceutical ingredients. It is also used as an odor agent, surface active agent and viscosity adjustor.
General Description
Chloroacetic acid sodium salt is a white colored powdered solid. Chloroacetic acid sodium salt is soluble in water.Chloroacetic acid sodium salt may be toxic ingestion or inhalation. Sodium chloroacetate is used as a contact herbicide and a component in other herbicides, an intermediate in the production of carboxymethyl-cellulose, and other synthetic organic chemicals.
Air & Water Reactions
Chloroacetic acid sodium salt is soluble in water.
Reactivity Profile
Salts, basic, such as Chloroacetic acid sodium salt, are generally soluble in water. The resulting solutions contain moderate concentrations of hydroxide ions and have pH's greater than 7.0. They react as bases to neutralize acids. These neutralizations generate heat, but less or far less than is generated by neutralization of the bases in reactivity group 10 (Bases) and the neutralization of amines. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
Health Hazard
Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.
Flammability and Explosibility
Nonflammable
Biochem/physiol Actions
Actin plays an important role in cell motility, structure and integrity. Smooth muscle actin-α (SMA)/ α2-smooth muscle actin (ACTA2) interacts with β-myosin heavy chain and helps in vascular smooth muscle cell contraction. The encoded protein modulates the expression of c-MET (tyrosine-protein kinase Met) and focal adhesion kinase (FAK) in human lung adenocarcinoma cells, which positively and selectively mediates tumor progression. Mutation in the gene expression leads to thoracic aortic aneurysms and dissections (TAAD).
Safety Profile
Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of Cland NazO. Used as an herbicide
Check Digit Verification of cas no
The CAS Registry Mumber 3926-62-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,9,2 and 6 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 3926-62:
(6*3)+(5*9)+(4*2)+(3*6)+(2*6)+(1*2)=103
103 % 10 = 3
So 3926-62-3 is a valid CAS Registry Number.
InChI:InChI=1/C2H3ClO2/c3-1-2(4)5/h1H2,(H,4,5)
3926-62-3Relevant articles and documents
Preparation method of sodium o-methylphenoxyacetate in synthesis process of sodium 2-methyl-4-chlorophenoxyacetate
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Paragraph 0067; 0069; 0072-0090, (2021/08/14)
The invention relates to a preparation method of sodium o-methylphenoxyacetate in a synthesis process of sodium 2-methyl-4-chlorophenoxyacetate. The invention provides a preparation method of sodium o-methylphenoxyacetate, which comprises the following steps of: reacting o-cresol with sodium hydroxide to obtain a sodium o-cresol solution, reacting chloroacetic acid with sodium hydroxide to obtain a sodium chloroacetate solution, and reacting the sodium o-cresol with sodium chloroacetate under the condition of a catalyst to obtain the sodium o-methylphenoxyacetate. The catalyst is added in the preparation process, so that the reaction temperature and the decomposition rate of sodium chloroacetate can be effectively reduced, the conversion rate of o-cresol is improved, the problems of difficulty in later phenol-containing wastewater treatment and high energy consumption caused by low conversion rate of o-cresol are solved, and the preparation process is effectively simplified. Meanwhile, the sodium o-methylphenoxyacetate prepared by the preparation method is relatively high in purity and yield.
Novel pyrazolone derivatives and corresponding europium(III) complexes: Synthesis and properties research
Li, Dewei,Xiong, Suhao,Guo, Tiantong,Shu, Dehua,Xiao, Haihua,Li, Guizhi,Guo, Dongcai
, p. 28 - 35 (2018/05/24)
A series of pyrazolone derivatives ligands L1?7 were successfully synthesized and validated by 1H NMR and MS, corresponding europium complexes [EuL1?7(NO3)2]NO3·EtOAc were synthesized. Physico-chemistry properties of title complexes were determined by Elemental analysis, Molar conductance, UV absorption spectra, IR spectra and Thermogravimetric analysis. The title complexes exhibit characteristic red fluorescence of Eu3+. The effect of various substituent groups in ligands on the of title Eu3+ complexes is ordered: Cl > -Br > -OCH3 > -F > -CH3 > -H > -NO2, and [EuL6(NO3)2]NO3·EtOAc containing Cl possesses the strongest fluorescence intensity, so does fluorescence quantum yield. The electrochemical properties indicate that energy gap Eg and LUMO energy level are huge affected by substituent groups, and variation trends of LUMO energy level affected by diverse substituent groups are also different. The prepared title europium complexes have potential application prospects in the fields of photoelectric functional materials and life sciences.
Preparation method for 2,4-dichlorophenoxyacetic acid
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Paragraph 0053; 0054; 0056; 0058; 0060; 0062, (2018/09/29)
The invention provides a preparation method for 2,4-dichlorophenoxyacetic acid. The preparation method comprises the following steps: a) reacting 2,4-dichlorophenol with alkali to obtain a 2,4-dichlorophenolate reaction solution, drying the 2,4-dichlorophenolate reaction solution so as to obtain a 2,4-dichlorophenolate solid, reacting haloacetic acid with an alkali so as to obtain a haloacetate reaction solution and carrying out drying so as to obtain a haloacetate solid; B) reacting the 2,4-dichlorophenolate solid with the haloacetate solid so as to obtain 2,4-dichlorophenoxyacetate; and C) acidifying the 2,4-dichlorophenoxyacetate so as to obtain 2,4-dichlorophenoxyacetic acid. According to the invention, the 2,4-dichlorophenolate reaction solution and the haloacetate reaction solution are separately dried to remove water; and the 2,4-dichlorophenolate solid and the haloacetate solid are subjected to a reaction in a non-aqueous phase, so the reaction is more thorough, and the prepared 2,4-dichlorophenoxyacetic acid has high yield and purity.
