189955-92-8Relevant academic research and scientific papers
SAR in the alkoxy lactone series: The discovery of DFP, a potent and orally active COX-2 inhibitor
Leblanc,Roy,Boyce,Brideau,Chan,Charleson,Gordon,Grimm,Guay,Leger,Li,Riendeau,Visco,Wang,Webb,Xu,Prasit
, p. 2207 - 2212 (2007/10/03)
Extensive SAR has been established in the alkoxy lactone series and this has lead to the discovery of DFP (5,5-dimethyl-3-(2-propoxy)-4- methanesulfonylphenyl)-2(5H)-furanone), a potent COX-2 inhibitor exhibiting in vivo efficacy in all models studied.
