1900-40-9

Usage

Uses

Used in Analytical Chemistry:
N,N''-BIS-(4-NITRO-PHENYL)-MALONAMIDE is used as a chelating agent for the extraction and separation of metal ions, especially lanthanides and actinides, from aqueous solutions. Its high selectivity makes it a valuable tool in this field.
Used in Nuclear Waste Treatment:
In the industry of nuclear waste management, N,N''-BIS-(4-NITRO-PHENYL)-MALONAMIDE is utilized for the purification and treatment of nuclear waste, contributing to the safe handling and disposal of radioactive materials.
Used in Nuclear Fuel Reprocessing:
N,N''-BIS-(4-NITRO-PHENYL)-MALONAMIDE is also employed in the development of new separation methods for nuclear fuel reprocessing, enhancing the efficiency and safety of nuclear energy production.
Used in Material and Pharmaceutical Synthesis:
N,N''-BIS-(4-NITRO-PHENYL)-MALONAMIDE has been studied for its potential in the synthesis of new materials and pharmaceutical compounds, indicating its versatility beyond its traditional applications in analytical and nuclear chemistry.

Upstream product

• 100-01-6 4-nitro-aniline 
• 105-53-3 diethyl malonate 
• 13195-64-7 diisopropyl malonate 
• 1663-67-8 malonoyl dichloride 

Downstream Products

• 102117-65-7 2-Methoxyimino-N,N'-bis-(4-nitro-phenyl)-malonamide 
• 102117-59-9 2-Hydroxyimino-N,N'-bis-(4-nitro-phenyl)-malonamide 
• 90688-54-3 dichloro-malonic acid bis-(4-nitro-anilide) 

Relevant academic research and scientific papers

Isopropyl N-arylmalonamates. Synthesis, structure, conformation and reactions with carbon disulfide

Acylation of aromatic amines 1 with diisopropyl malonate (2) leads to a mixture of isopropyl N-arylmalonamates 3 and malonanilides 4. The reaction of 3 with carbon disulfide in the presence of sodium hydride gives disodium salts 5. Treatment of 5 with an alkylating agent yields the open-chain or cyclic ketene dithioacetals 6, 7 or 8. The molecular structure, hydrogen bonding and preferential conformation of the isopropyl N-arylmalonamates 3, 6 and 7 were investigated using correlation analyses of IR, 13C NMR and AMI semiempirical data.

Prostaglandin-H Synthase Inhibition by Malonamides. Ring-Opened Analogues of Phenylbutazone

Recent reports of serious concern regarding the sfe clinical use of phenylbutazone and its hydroxylated metabolite (oxyphenbutazone) as antiinflammatory agents have prompted the further investigation of ring-opened (malonamide) derivatives as potentially preferable therapeutic derivatives.Earlier reports have claimed reduced toxicity among similar derivatives.These studies reveal the relative degree of prostaglandin-H (PGH) synthase inhibitory activity among a series of malonamide derivatives.Contrary to observations in the pyrazolidinedione series, incorporation of a nonpolar butyl side chain in these malonamides was not beneficial but, rather, detrimental to enzyme-inhibitory activity.Although nine of the reported nonbutylated malonamides was a potent an inhibitor of this enzyme as phenylbutazone, they all showed some inhibitory activity.PGH synthase inhibitory activity was especially pronounced in the bis(p-hydroxy anilide) derivatives, even extending to succinamide and adipamide derivatives.Of some interest is the observation that all of these p-hydroxy anilide derivatives were more potent inhibitors of this enzyme than acetaminophen.

REACTION OF DIAZOMETHANE WITH HYDROXYIMINOMALONANILIDES

The structures of the yellow and white crystalline modifications of para-substituted hydroxyiminomalonanilides and their reaction with diazomethane under various conditions, leading to the corresponding nitrones and oxime O-ethers, were investigated.Proba