190060-63-0Relevant academic research and scientific papers
QUINOLONE CARBOXAMIDE CALPAIN INHIBITORS
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, (2008/06/13)
A compound of the formula STR1 wherein: Z is aryl, substituted aryl, phenyl-lower-alkyl, hetero-aryl, substituted heteroaryl, heterocycloalkyl, heterocyclocalkyl-lower-alkyl, hetero-aryl-lower-alkyl wherein one or more hydrogens of aryl and heteroaryl is optionally replaced by A and B;Y is lower cycloalkyl, aryl, phenyl-lower-alkyl, hetero-aryl, heterocycloalkyl, heterocyclocalkyl-lower-alkyl, hetero-aryl-lower-alkyl wherein one or more hydrogens of aryl and heteroaryl is optionally replaced by A and B;X is CONH. sub.2, CONHOH, tetrazole, SO 2 N(R) 2, PO(OH) 2, CON(R) 2, or CONR--CHR--CO--A or CONR--(CHR) n--A;A and B is independently H, OH, OR, halo, CF 3, lower alkyl, N(R) 2, CON(R) 2, SR, NHSO 2 R, hydroxy-lower-alkyl, NHCOR, NRSO 2 CF. sub.3, OSO 2 CF 3, or CN;R is H, lower-alkyl, phenyl-lower-alkyl, hydroxy-lower-alkyl, CO-lower-alkyl, or CO--(CH 2) n--aryl; andn is 1, 2, or 3, and a pharmaceutically acceptable salt thereof.
