190062-99-8Relevant academic research and scientific papers
Amino-acid zwitterion equilibria: vibrational and nuclear magnetic resonance studies of methyl-substituted thiazolidine-4-carboxylic acids
Howard-Lock, H. E.,Lock, C. J. L.,Martins, M. L.,Smalley, P. S.,Bell, R. A.
, p. 1215 - 1219 (1986)
Infrared and Raman spectra (4000-100 cm-1) of solid samples of six different methyl substituted thiazolidine products of D-penicillamine and L-cysteine hydrochloride have been observed and assigned, Infrared spectra in D2O solutions have been obtained for comparison in order to study the amino-acid zwitterion equilibria.Proton and 13C nmr spectra for the compounds have also been measured.
(+)-Meyeniins A-C, Novel Hexahydroimidazo[1,5-c]thiazole Derivatives from the Tubers of Lepidium meyenii: Complete Structural Elucidation by Biomimetic Synthesis and Racemic Crystallization
Zhou, Min,Ma, Hang-Ying,Liu, Zhi-Hua,Yang, Guang-Yu,Du, Gang,Ye, Yan-Qing,Li, Gan-Peng,Hu, Qiu-Fen
, p. 1887 - 1892 (2017)
(+)-Meyeniins A-C (1-3), a novel class of sulfur-containing hexahydroimidazo[1,5-c]thiazole derivatives, were isolated from the tubers of Lepidium meyenii (maca) cultivated in Lijiang, Yunnan province, China. Guided by their biosynthetic hypothesis, a ste
Synthetic preparation method and application of meyeniin A derivatives
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Paragraph 0033, (2017/09/02)
The invention discloses a synthetic preparation method and an application of meyeniin A derivatives (I and II). The synthetic route of the method is as shown in the description. The meyeniin A derivatives are synthetic derivatives (I and II) of meyeniin A. The compounds are a series of artificial analogues synthesized through a two-step chemical reaction with a novel natural alkaloid meyeniin A separated from a medicinal plant maca as a template and precursor cysteine as an initiating raw material. The meyeniin A derivatives are basically structurally characterized by being composed of a hexahydroimidazole[1,5-c] thiazole nuclear parent and a benzyl substituent of different substituents. The different substituents on a side chain substituent determine diversity of the compounds. The synthetic derivatives of meyeniin A are synthesized for the first time and part of the derivatives have potential bioactivity, so that the compounds can be used as lead compounds of anti-tumor drugs, and have certain research value and application prospect.
HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR INHIBITING LIPID ACCUMULATION CONTAINING SAME
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Page/Page column 61, (2008/12/04)
The present invention relates to a novel heterocyclic carboxylic acid derivative, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient for inhibiting the accumulation of lipids in the body.
Azafulvenium methides: New extended dipolar systems
Sutcliffe, Oliver B.,Storr, Richard C.,Gilchrist, Thomas L.,Rafferty, Paul
, p. 1795 - 1806 (2007/10/03)
The transient 1-azafulvenium methides 24, 26 and 28 generated by thermal extrusion of sulfur dioxide from pyrrolo[1,2-c][1,3]thiazole 2,2-dioxide 20 (R = Me), 22 and 23 undergo sigmatropic [1,8]H shifts and the 1-acyl derivatives 30 electrocyclise to give novel pyrrolo[1,2-c][1,3]oxazines 32. The analogous 1,2-diazafulvenium methide 36 has been intercepted in [8π + 2π] cycloadditions with electron-rich silylated acetylenes to give adducts 37-40. This behaviour is partially explained by Frontier MO theory.
2-Substituted thiazolidine-4(R)-carboxylic acids as prodrugs of L-cysteine. Protection of mice against acetaminophen hepatotoxicity
Nagasawa,Goon,Muldoon,Zera
, p. 591 - 596 (2007/10/02)
A number of 2-alkyl- and 2-aryl-substituted thiazolidine-4(R)-carboxylic acids were evaluated for their protective effect against hepatotoxic deaths produced in mice by LD90 doses of acetaminophen. 2(RS)-Methyl-(1b),2(RS)-n-propyl-, and 2(RS)-n
