190074-50-1

Usage

Uses

Used in Pharmaceutical Industry:
2,7-Dichloro-imidazo[1,2-a]pyridine is used as a building block and intermediate for the synthesis of various pharmaceutical drugs. Its unique structure allows for the development of compounds with specific biological and pharmacological activities, making it a valuable component in drug discovery and design.
Used in Agrochemical Industry:
In the agrochemical industry, 2,7-dichloro-imidazo[1,2-a]pyridine is utilized as a key intermediate in the production of crop protection agents. Its incorporation into these agents can enhance their effectiveness in protecting crops from pests and diseases, thereby contributing to increased agricultural productivity.
Used in Biological and Pharmacological Research:
2,7-Dichloro-imidazo[1,2-a]pyridine is employed as a subject of research in the fields of biology and pharmacology. Its potential as an inhibitor of certain enzymes and receptors has attracted interest, with ongoing studies aimed at understanding its mechanisms of action and exploring its therapeutic potential in various diseases and conditions.

Upstream product

• 19798-80-2 2-Amino-4-chloropyridine 
• 105-36-2 ethyl bromoacetate 

Relevant academic research and scientific papers

METHOD OF CONTROLLING HARMFUL ARTHROPOD USING HETEROCYCLIC COMPOUND

PROBLEM TO BE SOLVED: To provide a method of controlling harmful arthropods. SOLUTION: A compound represented by formula (I) or an N oxide thereof can control harmful arthropods [where Q is a group represented by Q1, or a group represented by Q2, Z is an oxygen atom or the like, A2, A3 and A6 each denote a nitrogen atom or the like, A4 is CR1a or the like, A5 is a nitrogen atom or the like, A7 is NR6g or the like, G1, G2, G3 and G4 each denote a nitrogen atom or the like, R1a is a C1-C6 chain hydrocarbon group substituted with one or more substituent selected from the group consisting of a cyano group and a halogen atom, or the like, R2 is a C1-C6 alkyl group optionally substituted with one or more halogen atom, or the like, and n is 0, 1 or 2]. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Imidazo[1,2-a]pyridine C-nucleosides as antiviral agents

This invention pertains to nucleoside analogs that have antiviral activity and improved metabolic stability, compositions comprising them, and methods of antiviral treatment employing them. More particularly, this invention pertains to imidazo[1,2-a]pyridine C-nucleosides, as exemplified by compounds such as imidazo[l,2-a]pyridine C5-nucleosides and imidazo[1,2-a]pyridine C3-nucleosides, and may be represented by formula (I), wherein exactly one of Q3and Q5is a sugar-like moiety; exactly one of Q3and Q5is —H; and Q2, Q6, Q7and Q8are independently imidazo[1,2-a]pyridine substituents, such as —H, —F, —Cl, —Br and —I.

An improved synthesis of 2-chlorinated imidazo[1,2-a]pyridines and the application of this procedure for the synthesis of several new polychlorinated imidazo[1,2-a]pyridines

Polychlorinated imidazo[1,2-a]pyridines were synthesized as analogs of certain chlorinated benzimidazoles. The imidazo[1,2-a]pyridines were obtained by a condensation of ethyl bromoacetate and chlorinated 2-aminopyridines. These condensation products were treated with an ion exchange resin to effect an exchange of hydrobromide salts with hydrochloride salts. These compounds were subsequently treated with POCl3 to convert the imidazo[1,2-a]pyridin-2-ones into 2-chloroimidazo[1,2-a]pyridines.