1901-68-4Relevant articles and documents
Synthesis and in vitro Antibacterial Activity of Some Novel Fused Pyridopyrimidine Derivatives
El-Remaily, Mahmoud Abd El Aleem Ali Ali,El Hady,Salah Abo Zaid,Abd El-Raheem
, p. 1304 - 1309 (2016)
Pyridopyrimidine derivatives 2, 5 and 7, 8, 9 were furnished by the reaction of compound 1 with a variety of reagents, namely, formic acid, acetic anhydride, phenyl isothiocyanate, phenyl isocyanate, carbon disulfide, acetamide and thioacetamide, which in turn were treated with hydrazine to give pyrazolopyridopyrimidine derivatives 4, 6 and 11, 12, 13. The potency of the results as antibacterial agents has been evaluated. Most of the tested products showed a highly inhibition zone against the two bacterial strains. All compounds have been characterized based on their IR,1H-NMR and Mass spectra.
Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors
Chioua, Mourad,Samadi, Abdelouahid,Soriano, Elena,Lozach, Olivier,Meijer, Laurent,Marco-Contelles, Jose
supporting information; experimental part, p. 4566 - 4569 (2010/04/24)
The synthesis and biological evaluation of a number of differently substituted 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives are reported. From the inhibition results on a selection of disease-relevant protein kinases [IC50 (μM) DYRK1A = 11; CDK5 = 0.41; GSK-3 = 1.5] we have observed that 3,6-diamino-4-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile (4) constitutes a potential new and simple lead compound in the search of drugs for the treatment of Alzheimer's disease.
