1901-69-5

Basic information

• Product Name: 3,6-diamino-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile
• CAS NO: 1901-69-5
• Molecular Formula: C₈H₈N₆
• Molecular Weight: 188.1893
• Mol File: 1901-69-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 495.9°C at 760 mmHg
• Flash Point: 253.7°C
• Density: 1.65g/cm³
• Vapor Pressure: 5.68E-10mmHg at 25°C
• Refractive Index: 1.826
• CAS DataBase Reference: 3,6-diamino-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-diamino-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile(1901-69-5)
• EPA Substance Registry System: 3,6-diamino-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile(1901-69-5)

Safety Data

• Hazardous Substances Data: 1901-69-5(Hazardous Substances Data)

Upstream product

• 51768-01-5 2-amino-6-chloropyridine-3,5-dicarbonitrile 
• 60-34-4 methylhydrazine 

Relevant articles and documents

Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors

The synthesis and biological evaluation of a number of differently substituted 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives are reported. From the inhibition results on a selection of disease-relevant protein kinases [IC50 (μM) DYRK1A = 11; CDK5 = 0.41; GSK-3 = 1.5] we have observed that 3,6-diamino-4-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile (4) constitutes a potential new and simple lead compound in the search of drugs for the treatment of Alzheimer's disease.