190144-08-2

Upstream product

• 173658-50-9 (1S,2S)-cyclohexane-1,2-dimethanol bis(methanesulfonate) 
• 7436-01-3 (1S)-trans-1,2-bis-(toluene-4-sulfonyloxymethyl)-cyclohexane 
• 610-10-6 (1S,2S)-cyclohexane-1,2-dicarboxylic acid 
• 3205-34-3 (1S,2S)-(–)-1,2-di(hydroxymethyl)cyclohexane 
• 2305-32-0 trans-1,2-cyclohexanedicarboxylic acid 

Relevant academic research and scientific papers

Synthesis of new C2-symmetrical diphosphines using chiral zinc organometallics

The new C2-symmetrical diphosphines 1-4 of potential interest for asymmetric catalysis were prepared in protected form by a convergent synthesis based on the use of readily available (S,S)-1,2-cyclohexanedicarboxylic acid 8 and the phosphorus reagent (Et2N)2PLi·BH3.

Asymmetric Ring-Closing Metathesis Catalyzed by Chiral Molybdenum Alkylidene Complexes

Kinetic resolution was observed in ring-closing metathesis of racemic dienes catalyzed by the newly developed chiral molybdenum alkylidene complexes (R,R)-Mo(CHCMe2Ph)(NAr)(TBEC) 1 (Ar = 2,6-i-Pr2C6H3, TBEC = 2′,2′ ,2″,2″-tetrakis(trifluoromethyl)-1,2-bis(2′-hydroxyethyl) cyclopentane) and (R,R)-Mo(CHCMe2Ph)(NAr)(TBEH) 2 (Ar - 2,6-i-Pr2C6H3, TBEH = 2′,2′,2″,2″-tetrakis(trifluoro- methyl)-1,2-bis(2′-hydroxyethyl)cyclohexane). In the case of a prochiral symmetric triene substrate, optically active cyclized product was formed by catalytic ring-closing metathesis with 1, which opens the possibility of a new version of two-directional synthesis. Although the observed enantiomeric excesses were modest to low, this data demonstrates the feasibility of asymmetric induction by chiral alkylidene catalysts in ring-closing metathesis.