3205-34-3

Basic information

• Product Name: [1S,2S,(-)]-1,2-Cyclohexanedimethanol
• Synonyms: [(1S,2S)-2-(hydroxymethyl)cyclohexyl]methanol;[1S,2S,(-)]-1,2-Cyclohexanedimethanol;(1S,2S)-Cyclohexane-1,2-dimethanol;(S,S)-1,2-Bis(hydroxymethyl)cyclohexane;(1S,2S)-Cyclohexane-1,2-diyldiMethanol
• CAS NO: 3205-34-3
• Molecular Formula: C₈H₁₆O₂
• Molecular Weight: 144.21
• EINECS: 1308068-626-2
• Mol File: 3205-34-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 60-63℃
• Boiling Point: 270℃
• Flash Point: 129℃
• Appearance: /
• Density: 1.004
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: [1S,2S,(-)]-1,2-Cyclohexanedimethanol(CAS DataBase Reference)
• NIST Chemistry Reference: [1S,2S,(-)]-1,2-Cyclohexanedimethanol(3205-34-3)
• EPA Substance Registry System: [1S,2S,(-)]-1,2-Cyclohexanedimethanol(3205-34-3)

Safety Data

• Hazardous Substances Data: 3205-34-3(Hazardous Substances Data)

Usage

Uses

(1S,?2S)?-1,?2-?Cyclohexanedimethano?l is an intermediate used to synthesize C2-?symmetrical diphosphines using chiral zinc organometallics.

Upstream product

• 31982-90-8 (1S,2S)-(+)-cyclohexane-1,2-dicarboxylic acid dimethyl ester 
• 15679-27-3 (4S,5S)-4,5-bis(hydroxymethyl)cyclohexene 
• 76155-27-6 (+/-)-trans-2-(hydroxymethyl)cyclohexylmethanol 
• 610-10-6 (1S,2S)-cyclohexane-1,2-dicarboxylic acid 
• 2305-32-0 trans-1,2-cyclohexanedicarboxylic acid 

Downstream Products

• 367514-88-3 (3aR,4S,7R,7aS)-2-[((1R,2R)-2-{[4-(l1,2-benzisothiazol-3-yl)piperazin-1-yl]methyl}cyclohexyl)methyl]hexahydro-1H-4,7-methanisoindol-1,3-dione hydrochloride 
• 194861-74-0 lurasidone 
• 38261-85-7 (1S,2S)-1,2-bis(bromomethyl)cyclohexane 
• 173827-86-6 (1R,2R)-cyclohexane-1,2-diacetonitrile 
• 7436-01-3 (1S)-trans-1,2-bis-(toluene-4-sulfonyloxymethyl)-cyclohexane 
• 190144-08-2 (1S,2S)-1,2-Bis-iodomethyl-cyclohexane 
• 173658-50-9 (1S,2S)-cyclohexane-1,2-dimethanol bis(methanesulfonate) 

Relevant articles and documents

Development of effective bidentate diphosphine ligands of ruthenium catalysts toward practical hydrogenation of carboxylic acids

Hydrogenation of carboxylic acids (CAs) to alcohols represents one of the most ideal reduction methods for utilizing abundant CAs as alternative carbon and energy sources. However, systematic studies on the effects of metal-to-ligand relationships on the catalytic activity of metal complex catalysts are scarce. We previously demonstrated a rational methodology for CA hydrogenation, in which CA-derived cationic metal carboxylate [(PP)M(OCOR)]+ (M = Ru and Re; P = one P coordination) served as the catalyst prototype for CA self-induced CA hydrogenation. Herein, we report systematic trial- and-error studies on how we could achieve higher catalytic activity by modifying the structure of bidentate diphosphine (PP) ligands of molecular Ru catalysts. Carbon chains connecting two P atoms as well as Ar groups substituted on the P atoms of PP ligands were intensively varied, and the induction of active Ru catalysts from precatalyst Ru(acac)3 was surveyed extensively. As a result, the activity and durability of the (PP)Ru catalyst substantially increased compared to those of other molecular Ru catalyst systems, including our original Ru catalysts. The results validate our approach for improving the catalyst performance, which would benefit further advancement of CA self-induced CA hydrogenation.

[6+5] FUSED BICYCLES AS A THROMBIN ANTAGONIST, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE BICYCLES

The present invention relates to the new [6+5] fused bicycle derivatives, pharmaceutically acceptable salts or isomers thereof, processes for preparing the same, and pharmaceutical compositions comprising the same. The [6+5] fused bicycle derivatives can antagonize the thrombin receptor and thus may be effectively used for the treatment and prevention of thrombus, platelet aggregation, atherosclerosis, restenosis, blood coagulation, hypertension, arrhythmia, angina pectoris, heart failure, inflammation and cancer when used alone or with other cardiovascular agents.

Design and synthesis of a novel three-hindered quadrant bisphosphine ligand and its application in asymmetric hydrogenation

A novel three hindered quadrant bisphosphine ligand has been synthesized. The ligand shows excellent enantioselectivities and reactivities for rhodium-catalyzed hydrogenations of various functionalized olefins.