190182-60-6Relevant academic research and scientific papers
The discovery of carboline analogs as potent MAPKAP-K2 inhibitors
Wu, Jiang-Ping,Wang, Ji,Abeywardane, Asitha,Andersen, Denise,Emmanuel, Michel,Gautschi, Elda,Goldberg, Daniel R.,Kashem, Mohammed A.,Lukas, Susan,Mao, Wang,Martin, Leslie,Morwick, Tina,Moss, Neil,Pargellis, Christopher,Patel, Usha R.,Patnaude, Lori,Peet, Gregory W.,Skow, Donna,Snow, Roger J.,Ward, Yancey,Werneburg, Brian,White, Andre
, p. 4664 - 4669 (2008/02/13)
The discovery of a series of potent, carboline-based MK2 inhibitors is described. These compounds inhibit MK2 with IC50s as low as 10 nM, as measured in a DELFIA assay. An X-ray crystal structure reveals that they bind in a region near the p-lo
Synthesis of 3-Amino-2-(3-indolyl)propanol and propanoate derivatives and preliminary cardiovascular evaluation in rats
Perez-Alvarez, Victor,Morales-Rios, Martha S.,Hong, Enrique,Joseph-Nathan, Pedro
, p. 246 - 252 (2007/10/03)
A series of tryptamine analogues has been prepared and tested for their 5-HT1 receptor agonist properties. The incorporation of an alkoxy group at the C-5 position of the indole nucleus resulted in a short-lived and dose-dependent immediate ant
