190183-89-2

Upstream product

• 190183-87-0 methyl 2-methoxyimino-3-[(2R,3S,4R)-2,3-O-isopropylidenedioxy-4-t-butoxycarbonylaminocyclohexylidene]propionate 
• 503817-69-4 (1S,4R,7S,8S)-7,8-O-isopropylidenedioxy-3-t-butoxycarbonyl-3-aza-2-oxabicyclo[2.2.2]oct-5-ene 
• 190183-78-9 (2S,3S,4R)-2,3-O-isopropylidenedioxy-4-t-butoxycarbonylaminocyclohexanone 
• 138145-77-4 (1S,4R,7S,8S)-(+)-7,8-O-Isopropylidenedioxy-2-oxa-3-azabicyclo<2.2.2>oct-5-ene hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 190183-92-7 methyl 2-methoxyimino-3-(4R-benzyloxycarbonylamino-2-cyclohexenylidene)propionate 
• 190183-81-4 methyl 2-methoxyimino-3-(4R-t-butoxycarbonylamino-2-cyclohexenylidene)propionate 
• 503817-78-5 methyl 2-methoxyimino-3-(4R-acetamido-2-cyclohexenylidene)propionate 

Relevant academic research and scientific papers

Determination of the absolute configuration and total synthesis of radiosumin, a trypsin inhibitor from a freshwater blue-green alga

Radiosumin (1), a novel potent trypsin inhibitory dipeptide isolated from a freshwater blue-green alga Plectonemo radiosum (NIES-515), was synthesized for the first time, which unambiguously determined the absolute configuration.

Total synthesis and absolute configuration of radiosumin, a strong trypsin inhibitor from the blue-green alga Plectonema radiosum

Radiosumin (1), a strong trypsin inhibitory dipeptide isolated from the freshwater blue-green alga Plectonema radiosum (NIES-515), was synthesized for the first time by use of the hetero Diels-Alder reaction, the Horner-Wadsworth-Emmons reaction, the Corey-Winter reaction, regioselective hydrogenation, and reduction with zinc and formic acid as key steps, which unambiguously determined the absolute configuration of the structurally unique and biologically intriguing aquatic natural product (1).