190198-32-4

Upstream product

• 288-32-4 1H-imidazole 
• 104-95-0 (4-bromophenyl)thioanisole 
• 74-88-4 methyl iodide 

Downstream Products

• 578727-01-2 5-(4-fluorophenyl)-1-(4-methylthiophenyl)-1H-imidazole 
• 872544-80-4 1-[1-(4-methylsulfanylphenyl)-1H-2-imidazolyl]-1-cyclohexanol 
• 872544-83-7 2-chloro-1-(4-methylsulfanylphenyl)-1H-imidazole 
• 872544-87-1 2-iodo-1-(4-methylsulfanylphenyl)-1H-imidazole 
• 872544-81-5 1-[1-(4-methylsulfonylphenyl)-1H-2-imidazolyl]-1-cyclohexanol 
• 872544-84-8 2-chloro-1-(4-methylsulfonylphenyl)-1H-imidazole 
• 872544-88-2 2-(3-methoxyphenyl)-1-(4-methylsulfanylphenyl)-1H-imidazole 
• 851199-70-7 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazole 

Relevant academic research and scientific papers

Synthesis, characterization, and antileishmanial activities of gold(I) complexes involving quinoline functionalized N -heterocyclic carbenes

A series of new mononuclear cationic or neutral gold(I) complexes containing quinoline functionalized N-heterocyclic carbene(s) (NHC(s)) were synthesized and fully characterized by spectroscopic methods. The X-ray structures of two key compounds are presented. Proligands and their corresponding gold(I) complexes together with previously described silver(I) and gold(I) bis(NHC-quinoline) and gold(I) bis(NHC-methylbipyridine) complexes were evaluated in vitro towards Leishmania infantum. In parallel, the in vitro cytotoxicity of these molecules was assessed on the murine macrophages J774A.1. All gold(I) compounds show potent antileishmanial activity against L. infantum promastigotes and three of them are also efficient against L. infantum intracellular amastigotes. Structure-activity and toxicity relationships enables to evidence a lead-compound (6) displaying both a high activity and a good selectivity index.

Palladium-Catalyzed ipso-Borylation of Aryl Sulfides with Diborons

A catalytic Miyaura-type ipso-borylation of aryl sulfides with diboron reagents has been achieved, providing arylboronate esters of synthetic use. The key conditions to transform inherently reluctant C-S bonds into C-B bonds include a palladium-NHC (N-heterocyclic carbene) precatalyst, bis(pinacolato)diboron, and lithium hexamethyldisilazide. This protocol is applicable to a reasonable range of aryl alkyl sulfides. Twofold borylation was observed in the reaction of diphenyl sulfide.

Copper-catalyzed C-N bond formation with N-heterocycles and aryl halides

The microwave-assisted, cuprous oxide catalyzed coupling of aryl bromides and iodides with imidazole, benzimidazole, pyrazole, or triazole was found to give a wide range of N-aryl heteroaromatic products in good to high yields. Aryl dibromides undergo sel

Regioselective synthesis of 1,5-diaryl-1H-imidazoles by palladium-catalyzed direct arylation of 1-aryl-1H-imidazoles

A variety of 1,5-diaryl-1H-imidazoles have been regioselectively synthesized by direct coupling of 1-aryl-1H-imidazoles with aryl iodides or bromides in DMF in the presence of CsF as the base and a catalyst precursor consisting of a mixture of Pd(OAc)sub