190260-66-3Relevant academic research and scientific papers
Rhodium-catalyzed coupling of α-lactams with indole derivatives
Box, Hannah K.,Upul Kumarasinghe,Nareddy, Radhika R.,Akurathi, Gopalakrishna,Chakraborty, Amarraj,Raji, Babatunde,Rowland, Gerald B.
, p. 9709 - 9717 (2015/02/02)
We report herein a method that allows for the formation of a C-N bond between the C-3 carbon of α-lactams and the nitrogen atom of indoles. A general procedure for the coupling of indoles and α-lactams in only 25 min with high yield is reported. The scope of the reaction was extended by the development of a method for the in situ generation of less stable phenyl-substituted α-lactams. The developed method provides an atom-economical method for the formation of substituted α-amino amides that are found in a variety of biologically-active compounds.
A high-yielding general synthesis of α-lactams
Cesare, Victor,Lyons, Theresa M.,Lengyel, Istvan
, p. 1716 - 1720 (2007/10/03)
A high-yielding general synthesis of α-lactams (aziridinones) is described. An α-haloamide 1 precursor is cyclized by sodium hydride in the presence of 15-crown-5 ether at room temperature, using dichloromethane as the solvent. The by-products, hydrogen gas and sodium halide, are easily removed. The yields for the six known α-lactams (2b-g) chosen for this study are comparable or superior to previously reported yields,6,7,11,19-21 yet only short reaction times and a simple work-up is required.
About 1-triphenylmethyl-3-tert-butylaziridinone and some of its reactions [1]
Lengyel,Cesare,Karram,Taldone
, p. 997 - 1002 (2007/10/03)
A high-yield synthesis of 1-triphenylmethyl-3-tert-butylaziridinone (4), its physical and spectral proper- ties, the limits of its thermal stability, and reactions with methanol, benzylamine and sodium methoxide in methanol are described.
Reactivity of 1,3-di-tert-butylaziridinones with phenyl substituents. A new fragmentation of α-lactams
Shimazu, Masako,Endo, Yasuyuki,Shudo, Koichi
, p. 735 - 744 (2007/10/03)
Several isolable aziridinones with bulky substituents were prepared and their reactions with nucleophiles, i.e., methanol, sodium methoxide and benzylamine, were investigated. A novel fragmentation of aziridinones having a phenyl group on the C3 moiety was found.
