190263-27-5Relevant academic research and scientific papers
4-substituted-5(3)-carbamoyl-3(5)-(2-deoxy-β-D- ribofuranosyl)pyrazoles. Application of palladium catalyzed glycal coupling methodology to the synthesis of pyrazofurin analogs
Erion, Mark D.,Rydzewski, Robert M.
, p. 315 - 337 (2007/10/03)
Analogs of the C-nucleoside pyrazofurin were prepared in 7-9 steps using a key Pd(0)-catalyzed coupling reaction between protected iodopyrazoles 6a and 6b and glycal 8 to form the glycosyl bond. Conditions for this reaction were improved from those previously described for related reactions in order to maximize product yields and eliminate the need for triphenylarsine.
