190263-32-2

Basic information

• Product Name: 4-Bromo-5-((2R,5R)-5-hydroxymethyl-4-oxo-tetrahydro-furan-2-yl)-2-(tetrahydro-pyran-2-yl)-2H-pyrazole-3-carboxylic acid methyl ester
• CAS NO: 190263-32-2
• Molecular Weight: 403.23
• Mol File: 190263-32-2.mol

Chemical Properties

• CAS DataBase Reference: 4-Bromo-5-((2R,5R)-5-hydroxymethyl-4-oxo-tetrahydro-furan-2-yl)-2-(tetrahydro-pyran-2-yl)-2H-pyrazole-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-5-((2R,5R)-5-hydroxymethyl-4-oxo-tetrahydro-furan-2-yl)-2-(tetrahydro-pyran-2-yl)-2H-pyrazole-3-carboxylic acid methyl ester(190263-32-2)
• EPA Substance Registry System: 4-Bromo-5-((2R,5R)-5-hydroxymethyl-4-oxo-tetrahydro-furan-2-yl)-2-(tetrahydro-pyran-2-yl)-2H-pyrazole-3-carboxylic acid methyl ester(190263-32-2)

Safety Data

• Hazardous Substances Data: 190263-32-2(Hazardous Substances Data)

Upstream product

• 130277-32-6 ((2R,3S)-3-(tert-butyldiphenylsilyloxy)-2,3-dihydrofuran-2-yl)methanol 
• 190263-26-4 4-Bromo-5-iodo-2-(tetrahydro-pyran-2-yl)-2H-pyrazole-3-carboxylic acid methyl ester 

Relevant articles and documents

4-substituted-5(3)-carbamoyl-3(5)-(2-deoxy-β-D- ribofuranosyl)pyrazoles. Application of palladium catalyzed glycal coupling methodology to the synthesis of pyrazofurin analogs

Analogs of the C-nucleoside pyrazofurin were prepared in 7-9 steps using a key Pd(0)-catalyzed coupling reaction between protected iodopyrazoles 6a and 6b and glycal 8 to form the glycosyl bond. Conditions for this reaction were improved from those previously described for related reactions in order to maximize product yields and eliminate the need for triphenylarsine.