4-substituted-5(3)-carbamoyl-3(5)-(2-deoxy-β-D- ribofuranosyl)pyrazoles. Application of palladium catalyzed glycal coupling methodology to the synthesis of pyrazofurin analogs

Article abstract of DOI:10.1080/07328319708001352

Analogs of the C-nucleoside pyrazofurin were prepared in 7-9 steps using a key Pd(0)-catalyzed coupling reaction between protected iodopyrazoles 6a and 6b and glycal 8 to form the glycosyl bond. Conditions for this reaction were improved from those previously described for related reactions in order to maximize product yields and eliminate the need for triphenylarsine.

Full text of DOI:10.1080/07328319708001352

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Nucleosides and Nucleotides
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4-Substituted-5(3)-carbamoyl-3(5)-(2-
deoxy-β-D-ribofuranosyl)pyrazoles.
Application of Palladium Catalyzed
Glycal Coupling Methodology to the
Synthesis of Pyrazofurin Analogs
Mark D. Erion a & Robert M. Rydzewski a
a Gensia, Inc. , 9390 Towne Centre Drive, San Diego, CA, 92121
Published online: 22 Aug 2006.
To cite this article: Mark D. Erion & Robert M. Rydzewski (1997) 4-Substituted-5(3)-carbamoyl-3(5)-(2-
deoxy-β-D-ribofuranosyl)pyrazoles. Application of Palladium Catalyzed Glycal Coupling Methodology
to the Synthesis of Pyrazofurin Analogs, Nucleosides and Nucleotides, 16:3, 315-337, DOI:
10.1080/07328319708001352
To link to this article: http://dx.doi.org/10.1080/07328319708001352
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