1903-68-0

Basic information

• Product Name: N,N-DIMETHYLPIPERIDINE-4-CARBOXAMIDE
• Synonyms: 4-piperidinecarboxamide, N,N-dimethyl-;Zinc01668206;N,N-dimethyl-4-piperidinecarboxamide;N,N-dimethylisonipecotamide
• CAS NO: 1903-68-0
• Molecular Formula: C₈H₁₆N₂O
• Molecular Weight: 156.2254
• Mol File: 1903-68-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 169-170 °C
• Boiling Point: 269.1 °C at 760 mmHg
• Flash Point: 116.5 °C
• Appearance: /
• Density: 0.991 g/cm³
• Vapor Pressure: 0.0074mmHg at 25°C
• PKA: 9.87±0.10(Predicted)
• CAS DataBase Reference: N,N-DIMETHYLPIPERIDINE-4-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIMETHYLPIPERIDINE-4-CARBOXAMIDE(1903-68-0)
• EPA Substance Registry System: N,N-DIMETHYLPIPERIDINE-4-CARBOXAMIDE(1903-68-0)

Safety Data

• Hazardous Substances Data: 1903-68-0(Hazardous Substances Data)

Usage

General Description

N,N-Dimethylpiperidine-4-carboxamide is a chemical compound with the molecular formula C9H18N2O. It is a derivative of piperidine and is commonly used as a chemical intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. N,N-Dimethylpiperidine-4-carboxamide has potential applications in the field of medicine, acting as an analgesic and anti-inflammatory agent. It is also used in the production of rubber accelerators and corrosion inhibitors. The compound is a white to off-white solid with a faint odor, and it is soluble in polar solvents such as water and alcohols. N,N-Dimethylpiperidine-4-carboxamide should be handled and stored according to the proper safety protocols and guidelines due to its potential health hazards.

InChI:InChI=1/C8H16N2O/c1-10(2)8(11)7-3-5-9-6-4-7/h7,9H,3-6H2,1-2H3/p+1

Upstream product

• 254905-58-3 4-(dimethylcarbamoyl)piperidine-1-carboxylic acid tert-butyl ester 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 10314-98-4 1-benzyloxycarbonylpiperidine-4-carboxylic acid 
• 887757-52-0 benzyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate 
• 108748-89-6 isonicotinic acid dimethylamide; hydrochloride 

Downstream Products

• 1445901-04-1 1-{4-[(N-isobutyl-1-phenylmethylsulfonamido)methyl]phenyl}-piperidine-4-carboxylic acid N,N-dimethylamide 
• 1443125-03-8 N⁴,N⁴-dimethyl-N¹-(3-((6-oxo-3-(o-tolylamino)pyridazin-1(6H)-yl)methyl)phenyl)piperidine-1,4-dicarboxamide 
• 1008518-80-6 1-{4-[2-(4-hydroxy-2-oxo-2H-pyridin-1-yl)-ethyl]-benzyl}-piperidine-4-carboxylic acid dimethylamide 

Relevant articles and documents

Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen

WNT signaling is frequently deregulated in malignancy, particularly in colon cancer, and plays a key role in the generation and maintenance of cancer stem cells. We report the discovery and optimization of a 3,4,5-trisubstituted pyridine 9 using a high-throughput cell-based reporter assay of WNT pathway activity. We demonstrate a twisted conformation about the pyridine-piperidine bond of 9 by small-molecule X-ray crystallography. Medicinal chemistry optimization to maintain this twisted conformation, cognisant of physicochemical properties likely to maintain good cell permeability, led to 74 (CCT251545), a potent small-molecule inhibitor of WNT signaling with good oral pharmacokinetics. We demonstrate inhibition of WNT pathway activity in a solid human tumor xenograft model with evidence for tumor growth inhibition following oral dosing. This work provides a successful example of hypothesis-driven medicinal chemistry optimization from a singleton hit against a cell-based pathway assay without knowledge of the biochemical target.

PYRIDINE AND PYRIMIDINE BASED COMPOUNDS AS WNT SIGNALING PATHWAY INHIBITORS FOR THE TREATMENT OF CANCER

The present invention relates to pyridine and pyrimidine based compounds, pharmaceutical compositions comprising these compounds and their potential use as therapeutic agents for the treatment and / or prevention of cancer.

2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION

A 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented by the generalformula (1): [Chemical formula 1] (1) or a pharmaceutically acceptable saltthereof. They are useful as a therapeutic/preventive agent for diabetes, diabeticnephropathy, or glomerulosclerosis.