1903-75-9

Usage

Uses

Used in Pharmaceutical Industry:
N-METHYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE is used as a building block for the preparation of nitrogen heterocyclic compounds that act as inhibitors of 3'',5''-cyclic nucleotide-specific phosphodiesterase 10 (PDE10). PDE10 is an enzyme that plays a role in the regulation of neurotransmitter signaling in the brain, and its inhibition has been linked to the treatment of various psychiatric and neurological disorders, such as schizophrenia and Huntington's disease. By using N-METHYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE as a starting material, researchers can develop novel PDE10 inhibitors with improved potency, selectivity, and pharmacokinetic properties, potentially leading to more effective treatments for these conditions.

Upstream product

• 6843-37-4 N-methylisonicotinamide 

Relevant academic research and scientific papers

SULFONAMIDE COMPOUNDS AND THE USE THEREOF IN THE TREATMENT OF CANCER

The present disclosure relates generally to a class of sulfonamide-based compounds, compositions containing the same and the therapeutic use of the compounds in the treatment of cancer.

NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS

Unsaturated nitrogen heterocyclic compounds of formula (I): (I), as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, Huntington's Disease, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

A highly efficient Pd-C catalytic hydrogenation of pyridine nucleus under mild conditions

A synergistic Pd-C catalytic hydrogenation of 4-pyridinecarboxamides straightforward to 4-piperidinecarboxamide hydrochlorides was developed in the presence of ClCH2CHCl2. It provided a novel strategy for highly efficient hydrogenati