1903008-80-9

Usage

Uses

1. Used in Pharmaceutical Industry:
N-5-[(4-4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl-2-pyrimidinyl)amino]-4-methoxy-2-(4-morpholinyl)phenylacrylamide is used as a key intermediate compound in the synthesis of heteroaryl pyrimidinylamine derivatives. These derivatives are known to modulate EGFR (Epidermal Growth Factor Receptor) mutant kinase activities, making them potential candidates for the development of EGFR tyrosine-kinase inhibitors.
2. Used in Cancer Treatment:
As a component of heteroaryl pyrimidinylamine compounds, N-5-[(4-4-[(dimethylamino)methyl]-3-phenyl-1-yl-2-pyrimidinyl)amino]-4-methoxy-2-(4-morpholinyl)phenylacrylamide may contribute to the development of targeted therapies for various types of cancer. By modulating EGFR mutant kinase activities, these compounds can potentially inhibit tumor growth and progression, offering a promising avenue for cancer treatment.
3. Used in Drug Development:
The unique molecular structure of N-5-[(4-4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl-2-pyrimidinyl)amino]-4-methoxy-2-(4-morpholinyl)phenylacrylamide makes it a valuable compound for further drug development. Its potential applications may extend beyond cancer treatment, as its properties could be harnessed for the development of novel therapeutics targeting other diseases and conditions.

Upstream product

• 26033-20-5 3-Phenyl-1H-pyrazole-4-carboxaldehyde 
• 506-59-2 N,N-dimethylammonium chloride 
• 1075705-01-9 4-fluoro-2-methoxy-5-nitro-phenylamine 
• 1802924-13-5 (4-fluoro-2-methoxy-5-nitrophenyl)carbamic acid tert-butyl ester 
• 625-36-5 2-chloropropionyl chloride 

Relevant academic research and scientific papers

NOVEL INTERMEDIATES USEFUL FOR THE SYNTHESIS OF AMINOPYRIMIDINE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND PROCESS FOR PREPARING AMINOPYRIMIDINE DERIVATIVES USING THE SAME

The present invention provides a novel process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. And also, the present invention provides novel intermediates useful for said process and processes for preparing the same.

IMPROVED PROCESS FOR PREPARING AMINOPYRIMIDINE DERIVATIVES

The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. And also, the present invention provides novel intermediates useful for said process and processes for preparing the same.

INTERMEDIATES USEFUL FOR THE SYNTHESIS OF A SELECTIVE INHIBITOR AGAINST PROTEIN KINASE AND PROCESSES FOR PREPARING THE SAME

The present invention provides intermediates useful for the synthesis of an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for m

COMPOUNDS AND COMPOSITIONS FOR MODULATING EGFR MUTANT KINASE ACTIVITIES

The present invention provides a new group of protein kinase inhibitors, aminopyrimidine derivatives, and pharmaceutically acceptable salts thereof that are useful for treating cell proliferative disease and disorder such as cancer and immune disease. The