190321-60-9

Upstream product

• 190321-58-5 ethyl 4-((6-chloro 1,3-benzodioxol-5-yl) methyl) 1-(2-cyanoethyl) 5-hydroxy 1H-pyrazole 3-carboxylate 
• 190321-59-6 ethyl 4-((6-chloro 1,3-benzodioxol-5-yl) methyl) 1-(2-cyanoethyl) 5-bromo 1H-pyrazole 3-carboxylate 
• 179110-50-0 diethyl 2-((6-chloro-1,3-benzodioxol-5-yl) methyl)-3-oxo 1,4-butanedioate 
• 179110-49-7 ethyl 6-chloro-1,3-benzodioxol-5-propanoate 
• 179110-48-6 (E)-3-(6-Chloro-benzo[1,3]dioxol-5-yl)-acrylic acid ethyl ester 
• 15952-61-1 6-chloropiperonal 
• 2550-36-9 Cyclohexylmethyl bromide 

Downstream Products

• 321201-26-7 4-(6-chloro-benzo[1,3]dioxol-5-ylmethyl)-2-cyclohexylmethyl-5-furan-2-yl-2H-pyrazole-3-carboxylic acid ethyl ester 
• 190321-61-0 4-(6-chloro-benzo[1,3]dioxol-5-ylmethyl)-2-cyclohexylmethyl-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid ethyl ester 
• 190321-63-2 ethyl 4-((6-chloro-1,3-benzodioxol-5-yl) methyl) 1-(cyclohexylmethyl) 3-(3-thienyl)-1H-pyrazole 5-carboxylate 
• 321201-23-4 ethyl 4-((6-chloro 1,3-benzodioxol-5-yl) methyl) 1-(cyclohexylmethyl) 3-(3-pyridinyl) 1H-pyrazole 5-carboxylate 
• 321201-24-5 4-(6-chloro-benzo[1,3]dioxol-5-ylmethyl)-2-cyclohexylmethyl-5-(4-methoxy-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Potent nonpeptide endothelin antagonists: Synthesis and structure-activity relationships of pyrazole-5-carboxylic acids

We have previously reported the identification of pyrazole-5-carboxylic acids as a new class of endothelin antagonists from low affinity pyrazol-5-ol ligands, which were obtained by random screening assays.1 We describe herein the synthesis and the structure-activity relationships (SARs) of these pyrazole-5-carboxylic acids with potent ET(A) selective, mixed ET(A)/ET(B) or moderately ET(B) selective antagonist activities. (C) 2000 Elsevier Science Ltd.