190384-94-2Relevant academic research and scientific papers
Synthesis and evaluation of a 2-benzothiazolylphenylmethyl ether class of histamine H4 receptor antagonists
Labeeuw, Olivier,Levoin, Nicolas,Billot, Xavier,Danvy, Denis,Calmels, Thierry,Krief, Stéphane,Ligneau, Xavier,Berrebi-Bertrand, Isabelle,Robert, Philippe,Lecomte, Jeanne-Marie,Schwartz, Jean-Charles,Capet, Marc
, p. 5263 - 5266 (2016/10/30)
Synthesis and biological evaluation of a new class of histamine H4receptor ligands, distinct from the previously reported chemotypes, are described. A virtual screening of our corporate compound collection identified a hit with an undesired dual H3R/H4R activity. Chemical exploration led to the discovery of a more potent and selective 2-benzothiazolylphenylmethyl ether lead compound.
On the reaction of chloroalkylbenzothiazoles with alkaloides
Florio, Saverio,Capriati, Vito,Colli, Gennara
, p. 5839 - 5846 (2007/10/03)
2-chloroalkylbenzothiazoles 1a-c react with alkoxides to give substitution and ring-expanded products 3 and 4. The substitution ring-enlargement competition much depends upon the solvent, the substitution reaction being preferred in alcohols and the ring-enlargement in DMF.
