190438-27-8

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 178456-74-1 (3aS,4S,6aS)-tert-butyl 4-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyl-6-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate 
• 190438-25-6 ((S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-{(4S,5R)-5-[(S)-11-(tert-butyl-dimethyl-silanyloxy)-13-methyl-tetradecyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-ethyl)-carbamic acid tert-butyl ester 
• 190438-22-3 ((S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-{(4S,5R)-5-[(S)-11-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-13-methyl-tetradec-2-ynyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-ethyl)-carbamic acid tert-butyl ester 

Downstream Products

• 135574-63-9 penaresidin B 
• 190438-30-3 (2S,3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(S)-11-(tert-butyl-dimethyl-silanyloxy)-13-methyl-tetradecyl]-4-(tert-butyl-diphenyl-silanyloxymethyl)-azetidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Novel asymmetric synthesis of penaresidin B as a potent actomyosin ATPase activator

An efficient and novel synthetic process is described for the preparation of an azetidine ring with the contiguous stereogenic centers and the total synthesis of penaresidin B by featuring the elaboration ofthe functionalized homochiral lactam derived from D-glutamic acid.