190448-61-4

Upstream product

• 92052-38-5 4-O-(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyl)-2,3,6-tri-O-acetyl-α-D-glucopyranosyl trichloracetimidate 
• 190448-46-5 (1S)-1-(4-fluorophenyl)-3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]propyl acetate 
• 66073-13-0 α-D-glucopyranose-4-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-2,3,6-triacetate 
• 5328-50-7 D-cellobiose octaacetate 
• 250330-69-9 4-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-2,3,6-tri-O-acetyl-α/β-D-glucopyranosyl trichloroacetimidate 

Relevant academic research and scientific papers

An in vitro assay for evaluation of small-molecule inhibitors of cholesterol absorption

Giving cholesterol the brush off: An intestinal brush border membrane vesicle assay has been devised for the convenient in vitro testing of small molecules for inhibition of cholesterol absorption. The assay was used to identify new nonhydrolyzable glycosides as potent cholesterol-absorption inhibitors and an oxazolidinone as an effective replacement of the β-lactam scaffold of ezetimibe (1).

Sugar-Substituted 2-Azetidinone Cholesterol Absorption Inhibitors: Enhanced Potency by Modification of the Sugar

A glucuronide conjugate of the potent 2-azetidinone cholesterol absorbtion inhibitor Sch 58235 was synthesized to confirm the structure of a metabolite isolated from in vivo sources.A series of 2-azetidinone glycosides was prepared via Schmidt trichloroim