190448-46-5

Usage

Uses

Used in Pharmaceutical Development:
2-Azetidinone, 3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-, (3R,4S)is used as a potential pharmaceutical agent for the development of new drugs. Its unique molecular structure, including fluorophenyl and hydroxyphenyl groups, may offer specific binding affinities and interactions with biological targets, making it a candidate for the treatment of various diseases.
Used in Organic Chemistry Research:
In the field of organic chemistry, 2-Azetidinone, 3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-, (3R,4S)serves as a research tool for studying the synthesis, reactivity, and properties of complex organic molecules. Its well-defined stereochemistry and functional groups provide opportunities for exploring asymmetric synthesis, chiral recognition, and the influence of molecular structure on chemical behavior.
Used in Medicinal Chemistry:
2-Azetidinone, 3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-, (3R,4S)is utilized in medicinal chemistry for the design and optimization of bioactive molecules. Its structural features, such as the 2-azetidinone ring and fluorinated substituents, may contribute to improved pharmacokinetic properties, selectivity, and potency in drug candidates targeting specific biological pathways or receptors.
Used in Drug Synthesis:
In the synthesis of pharmaceutical compounds, 2-Azetidinone, 3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-, (3R,4S)acts as a key intermediate or building block. Its versatile functional groups and chiral centers enable further chemical modifications and the creation of diverse drug-like molecules with potential therapeutic applications.
Used in Drug Discovery:
2-Azetidinone, 3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-, (3R,4S)is employed in drug discovery for high-throughput screening and hit identification. Its unique structural features may lead to the discovery of novel bioactive compounds with potential applications in various therapeutic areas, such as oncology, neurology, or infectious diseases.

Upstream product

• 163380-20-9 4(S)-(4-acetyloxyphenyl)-3(R)-(3(S)-acetyloxy-3-(4-fluorophenyl)propyl)-1-(4-fluorophenyl)-2-azetidinone 

Downstream Products

• 190448-62-5 Acetic acid (S)-1-(4-fluoro-phenyl)-3-{(3R,4S)-1-(4-fluoro-phenyl)-2-oxo-4-[4-((2S,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-azetidin-3-yl}-propyl ester 
• 190448-61-4 C₅₂H₅₇F₂NO₂₁ 
• 190448-56-7 (2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-{4-[(2S,3R)-3-[(S)-3-acetoxy-3-(4-fluoro-phenyl)-propyl]-1-(4-fluoro-phenyl)-4-oxo-azetidin-2-yl]-phenoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 851860-30-5 (1S)-1-(4-fluorophenyl)-3-[(3R,4S)-1-(4-fluorophenyl)-2-oxo-4-(4-{[(trifluoromethyl)sulfonyl]oxy}-phenyl)azetidin-3-yl]propyl acetate 
• 190448-57-8 [14C]-Ezetimibe glucuronide 

Relevant academic research and scientific papers

An in vitro assay for evaluation of small-molecule inhibitors of cholesterol absorption

Giving cholesterol the brush off: An intestinal brush border membrane vesicle assay has been devised for the convenient in vitro testing of small molecules for inhibition of cholesterol absorption. The assay was used to identify new nonhydrolyzable glycosides as potent cholesterol-absorption inhibitors and an oxazolidinone as an effective replacement of the β-lactam scaffold of ezetimibe (1).

Sugar-Substituted 2-Azetidinone Cholesterol Absorption Inhibitors: Enhanced Potency by Modification of the Sugar

A glucuronide conjugate of the potent 2-azetidinone cholesterol absorbtion inhibitor Sch 58235 was synthesized to confirm the structure of a metabolite isolated from in vivo sources.A series of 2-azetidinone glycosides was prepared via Schmidt trichloroim