190448-65-8

Upstream product

• 72692-06-9 methyl 2,3,4-tri-O-acetyl-D-glucopyranuronate 
• 175415-07-3 (3R,4S)-4-(4-Hydroxy-phenyl)-1-(4-methoxy-phenyl)-3-(3-phenyl-propyl)-azetidin-2-one 
• 20371-41-9 5-phenylvaleric acid chloride 
• 203795-15-7 (S)-3-{(R)-2-[(S)-(4-Benzyloxy-phenyl)-(4-methoxy-phenylamino)-methyl]-5-phenyl-pentanoyl}-4-phenyl-oxazolidin-2-one 
• 175415-06-2 (3R,4S)-4-(4-Benzyloxy-phenyl)-1-(4-methoxy-phenyl)-3-(3-phenyl-propyl)-azetidin-2-one 
• 157435-14-8 (S)-4-Phenyl-3-(5-phenyl-pentanoyl)-oxazolidin-2-one 

Relevant academic research and scientific papers

Sugar-substituted 2-azetidinones as cholesterol absorption inhibitors

The asymmetric synthesis of a glucuronide conjugate of the 2-azetidinone cholesterol absorption inhibitor Sch 48461 was accomplished to confirm the structure of a metabolite isolated from in vivo sources. Key features of this article include the asymmetric synthesis of 2-azetidinones by Evan's chiral oxazolidinone methodology and glucuronide formation by a Mitsunobu protocol.