20371-41-9Relevant articles and documents
Efficient and selective solid-phase synthesis of trans 3-alkyl β-lactams from nonactivated acid chlorides
Delpiccolo, Carina M. L.,Mata, Ernesto G.
, p. 4085 - 4088 (2004)
An efficient and stereoselective procedure for a rapid access to diverse trans 3-alkyl β-lactams by solid-phase methodology is described.
2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors
Arja, Khaled,Auno, Samuli,Dillemuth, Pyry M. J.,Kilpel?inen, Tommi P.,Lahtela-Kakkonen, Maija K.,My?h?nen, Timo T.,P?tsi, Henri T.,Wallén, Erik A. A.
supporting information, p. 1578 - 1584 (2021/10/04)
Different five-membered nitrogen-containing heteroaromatics in the position of the typical electrophilic group in prolyl oligopeptidase (PREP) inhibitors were investigated and compared to tetrazole. The 2-imidazoles were highly potent inhibitors of the pr
Enantioselective Remote C(sp3)-H Cyanation via Dual Photoredox and Copper Catalysis
Chen, Hui,Jin, Weiwei,Yu, Shouyun
supporting information, p. 5910 - 5914 (2020/08/12)
The remote C(sp3)-H cyanation of carboxamides has been described by merging photoredox and copper catalysis in a site-selective and enantiocontrolled manner. The protocol is the integration of photoinduced and nitrogen-centered radical-mediated intermolecular hydrogen atom transfer with chiral copper-complex-catalyzed radical cyanation. This strategy gives enantio-enriched cyanated amides in high yields.