19047-22-4

Basic information

• Product Name: 3,4-diformylbenzoic acid
• Synonyms: 3,4-diformylbenzoic acid
• CAS NO: 19047-22-4
• Molecular Weight: 178.144
• Mol File: 19047-22-4.mol

Chemical Properties

• CAS DataBase Reference: 3,4-diformylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-diformylbenzoic acid(19047-22-4)
• EPA Substance Registry System: 3,4-diformylbenzoic acid(19047-22-4)

Safety Data

• Hazardous Substances Data: 19047-22-4(Hazardous Substances Data)

Upstream product

• 19047-21-3 3,4-bis(dibromomethyl)benzoic acid 
• 619-04-5 3,4-dimethylbenzoic acid 

Downstream Products

• 1054312-54-7 C₃₅H₄₁N₃O₉ 
• 1026411-35-7 (3,4-bis-[1,3]dioxolan-2-yl-benzoylamino)-acetic acid ethyl ester 
• 1026031-16-2 (3,4-bis-[1,3]dioxolan-2-yl-benzoylamino)-acetic acid 
• 336129-82-9 7'-{3,4-bis[2-(1,3-dioxolanyl)]-benzoylamino}-3-{3,4-bis[2-(1,3-dioxolanyl)]-benzyloxy}-17-(cyclopropylmethyl)-6,7-didehydro-4,5α-epoxy-14-hydroxyindolo[2',3':6,7]-morphinan 
• 943600-47-3 3,4-bis-[2-(1,3-dioxolanyl)]-benzoic acid 

Relevant articles and documents

METHOD FOR CONJUGATING MOLECULES

Methods of conjugating two molecules are disclosed herein in which a non-polymeric aliphatic dialdehyde or non-polymeric aromatic dialdehyde is reacted with a compound comprising an amine (NH2) moiety to form a stable product under mild conditions.

Tuning a three-component reaction for trapping kinase substrate complexes

The upstream protein kinases responsible for thousands of phosphorylation events in the phosphoproteome remain to be discovered. We developed a three-component chemical reaction which converts the transient noncovalent substrate-kinase complex into a covalently cross-linked product by utilizing a dialdehyde-based cross-linker, 1. Unfortunately, the reaction of 1 with a lysine in the kinase active site and an engineered cysteine on the substrate to form an isoindole cross-linked product could not be performed in the presence of competing cellular proteins due to nonspecific side reactions. In order to more selectively target the cross-linkerto protein kinases in cell lysates, we replaced the weak, kinase- bindi ng adenosine moiety of 1 with a potent protein kinase inhibitor scaffold. In addition, we replaced the o-phthaldialdehyde moiety in 1 with a less-reactive thiophene-2,3-dicarboxaldehyde moiety. The combination of these two structural modifications provides for cross-linking of a cysteine-containing substrate to its corresponding kinase in the presence of competing cellular proteins.

o-naphthalenedicarboxaldehyde derivative of 7′-aminonaltrindole as a selective δ-opioid receptor affinity label

Incorporation of a naphthalene-dialdehyde moiety into the δ antagonist, 6′-aminonaltrindole afforded a potent, selective, irreversible δ-agonist 1. However, flow cytometry studies revealed no time-dependent specific fluorescence, suggesting that both Lys2

Affinity labels as tools for the identification of opioid receptor recognition sites

Affinity labels have proven to be useful tools in opioid research. We review experiments carried out with the μ opioid receptor affinity label, β-funaltrexamine (2), that support the concept of different recognition sites for μ opioid agonists and antagon