19050-62-5

Basic information

• Product Name: 2-AMINO-N-PHENETHYL-BENZAMIDE
• Synonyms: 2-amino-N-(2-phenylethyl)benzamide
• CAS NO: 19050-62-5
• Molecular Formula: C₁₅H₁₆N₂O
• Molecular Weight: 240.31
• Mol File: 19050-62-5.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 469.6°Cat760mmHg
• Flash Point: 237.8°C
• Appearance: /
• Density: 1.148g/cm³
• Vapor Pressure: 5.46E-09mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 2-AMINO-N-PHENETHYL-BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-PHENETHYL-BENZAMIDE(19050-62-5)
• EPA Substance Registry System: 2-AMINO-N-PHENETHYL-BENZAMIDE(19050-62-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 19050-62-5(Hazardous Substances Data)

Usage

General Description

2-AMINO-N-PHENETHYL-BENZAMIDE is a chemical compound with the molecular formula C15H15N3O. It is a derivative of benzamide and consists of a benzene ring with an amide group and an amino group attached to it. 2-AMINO-N-PHENETHYL-BENZAMIDE has applications in pharmaceuticals and medicine, where it can be used in the synthesis of various drugs. Additionally, it has been investigated for its potential pharmacological properties, including its effects on the central nervous system and as a potential anticancer agent. Its structural properties make it a promising candidate for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C15H16N2O/c16-14-9-5-4-8-13(14)15(18)17-11-10-12-6-2-1-3-7-12/h1-9H,10-11,16H2,(H,17,18)

Upstream product

• 201230-82-2 carbon monoxide 
• 615-43-0 2-iodophenylamine 
• 64-04-0 phenethylamine 
• 91-56-5 indole-2,3-dione 
• 100-42-5 styrene 
• 28144-70-9 anthranilic acid amide 
• 612-25-9 2-Nitrobenzyl alcohol 
• 118-48-9 isatoic anhydride 

Downstream Products

• 4059-71-6 3-(2-phenylethyl)quinazoline-2,4(1H,3H)-dione 
• 1221177-08-7 C₃₆H₃₆N₄O₂ 

Relevant articles and documents

Unusual Acid- and Base-Catalyzed C-N Bond Formation Approach through Reaction of Chromonyl Meldrum's Acid and Nitrogen Binucleophiles

Reaction of chromonyl Meldrum's acid and N-substituted 2-aminobenzamides was studied in the presence of acidic and basic catalysts. The use of methanesulfonic acid as a catalyst in this reaction led to the synthesis of chromonyl quinazolinones through employing Meldrum's acid as a carbon leaving group. However, in the presence of basic catalyst, this reaction gave functionalized 2-pyridones.

Base-Mediated Anti-Markovnikov Hydroamidation of Vinyl Arenes with Arylamides

We investigated a base-promoted protocol for the intermolecular anti-Markovnikov hydroamidation of vinyl arenes with arylamides to furnish the arylethylbenzamides with excellent chemo- and regioselectivity. The reaction tolerates an extensive variety of functional groups and has been successfully extended with electronically varied handles, aminobenzamides, electron-rich/electron-deficient heterocyclic amides, and vinyl arenes to afford the hydroamidated products. Excellent chemoselectivity was observed for the amide group over amine. The proposed mechanism and vital role of the solvent was well supported by deuterium labeling studies and control experiments.

Electrochemical utilization of methanol and methanol-d4 as a C1 source to access (deuterated) 2,3-dihydroquinazolin-4(1H)-one

Herein, an electrocatalytic protocol for the synthesis of 2,3-dihydroquinazolin-4(1H)-one has been disclosed. Methanol is activated and utilized as the C1 source to cyclize with 2-aminobenzamides. This cyclization reaction proceeds conveniently (room temperature and air atmosphere) without any homogeneous metal catalysts, external oxidants, or bases. A wide variety of N,N-disubstituted 2,3-dihydroquinazolin-4(1H)-ones are obtained via this approach. Moreover, when methanol-d4 is used, a deuterated methylene motif is incorporated into the N-heterocycles, providing an efficient approach to the deuterated N-heterocycles.