190508-37-3

Basic information

• Product Name: (2S,4R)-1-((2R,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-4-(pyridin-4-ylmethoxy)-piperidine-2-carboxylic acid tert-butylamide
• Synonyms: (2S,4R)-1-((2R,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-4-(pyridin-4-ylmethoxy)-piperidine-2-carboxylic acid tert-butylamide
• CAS NO: 190508-37-3
• Molecular Weight: 454.613
• Mol File: 190508-37-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,4R)-1-((2R,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-4-(pyridin-4-ylmethoxy)-piperidine-2-carboxylic acid tert-butylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-1-((2R,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-4-(pyridin-4-ylmethoxy)-piperidine-2-carboxylic acid tert-butylamide(190508-37-3)
• EPA Substance Registry System: (2S,4R)-1-((2R,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-4-(pyridin-4-ylmethoxy)-piperidine-2-carboxylic acid tert-butylamide(190508-37-3)

Safety Data

• Hazardous Substances Data: 190508-37-3(Hazardous Substances Data)

Upstream product

• 123054-12-6 (2S)-N,N-dibenzylphenylalaninal 
• 175671-47-3 (2S,4R)-4-hydroxypipecolic tert-butylamide 
• 175476-94-5 N-<(S)-2-phenylethyl>-(2S,4R)-4-hydroxypipecolic acid tert-butylamide 
• 175476-95-6 (2S,4R)-4-hydroxypipecolic acid tert-butylamide 
• 111060-52-7 (S)-2-(dibenzylamino)-3-phenylpropan-1-ol 
• 165727-45-7 tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate 
• 98760-08-8 (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester 
• 190508-41-9 (2S,4R)-4-(Pyridin-4-ylmethoxy)-piperidine-2-carboxylic acid tert-butylamide 

Relevant articles and documents

Practical, stereoselective synthesis of palinavir, a potent HIV protease inhibitor

Palinavir is a potent peptidomimetic-based HIV protease inhibitor. We have developed a highly convergent and stereoselective synthesis which is amenable to the preparation of multikilogram quantities of this compound. The synthetic sequence proceeds in 24 distinct chemical steps (with several integrated, multistep operations) from commercially available starting materials. No chromatographies are required throughout the process, and the final product is purified by crystallization of its dihydrochloride salt to >99% homogeneity.