175476-94-5Relevant academic research and scientific papers
Practical, stereoselective synthesis of palinavir, a potent HIV protease inhibitor
Beaulieu, Pierre L.,Lavallee, Pierre,Abraham, Abraham,Anderson, Paul C.,Boucher, Colette,Bousquet, Yves,Duceppe, Jean-Simon,Gillard, James,Gorys, Vida,Grand-Maitre, Chantal,Grenier, Louis,Guindon, Yvan,Guse, Ingrid,Plamondon, Louis,Soucy, Francois,Valois, Serge,Wernic, Dominik,Yoakim, Christiane
, p. 3440 - 3448 (2007/10/03)
Palinavir is a potent peptidomimetic-based HIV protease inhibitor. We have developed a highly convergent and stereoselective synthesis which is amenable to the preparation of multikilogram quantities of this compound. The synthetic sequence proceeds in 24 distinct chemical steps (with several integrated, multistep operations) from commercially available starting materials. No chromatographies are required throughout the process, and the final product is purified by crystallization of its dihydrochloride salt to >99% homogeneity.
