190510-96-4

Basic information

• Product Name: Naphthalene-2-sulfonic acid [(S)-2-azepan-1-yl-1-(4-cyano-benzyl)-2-oxo-ethyl]-amide
• CAS NO: 190510-96-4
• Molecular Weight: 461.585
• Mol File: 190510-96-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Naphthalene-2-sulfonic acid [(S)-2-azepan-1-yl-1-(4-cyano-benzyl)-2-oxo-ethyl]-amide(CAS DataBase Reference)
• NIST Chemistry Reference: Naphthalene-2-sulfonic acid [(S)-2-azepan-1-yl-1-(4-cyano-benzyl)-2-oxo-ethyl]-amide(190510-96-4)
• EPA Substance Registry System: Naphthalene-2-sulfonic acid [(S)-2-azepan-1-yl-1-(4-cyano-benzyl)-2-oxo-ethyl]-amide(190510-96-4)

Safety Data

• Hazardous Substances Data: 190510-96-4(Hazardous Substances Data)

Upstream product

• 131724-45-3 (S)-2-((tert-butoxycarbonyl)amino)-3-(4-cyanophenyl)propanoic acid 
• 146664-08-6 N-acetyl-4-cyano-D,L-phenylalanine 
• 17201-43-3 4-cyanobenzyl bromide 
• 52117-01-8 N-acetyl-4-cyano-α-(ethoxycarbonyl)phenylalanine ethyl ester 
• 93-11-8 2-Naphthalenesulfonyl chloride 

Relevant articles and documents

Rational design of selective thrombin inhibitors

Thrombin inhibitors with functionalized benzamidines as surrogates for arginine were designed, synthesized, and characterized. Amino acid sequence difference in the position 190 between thrombin and trypsin was exploited in the design to enhance selectivity over trypsin. A representative compound 6 showed high potency (Ki of 45.5 nM) and extremely high specificity over trypsin (over 10,000 fold).