Bioorganic and Medicinal Chemistry Letters p. 769 - 774 (1997)
Update date:2022-08-05
Topics:
Kim, Sangsoo
Hwang, Sang Yeul
Kim, Young Kwan
Yun, Mikyung
Oh, Yeong Soo
Thrombin inhibitors with functionalized benzamidines as surrogates for arginine were designed, synthesized, and characterized. Amino acid sequence difference in the position 190 between thrombin and trypsin was exploited in the design to enhance selectivity over trypsin. A representative compound 6 showed high potency (Ki of 45.5 nM) and extremely high specificity over trypsin (over 10,000 fold).
View MoreContact:+86-27-67841589
Address:Add: 999 Gaoxin Road, Donghu New Technology Development Zone, Wuhan City, Hubei, China
Synchem Pharma Co.,Ltd(expird)
Contact:+0086-21-61984905-1
Address:Building 60,Zimian Park, LongYang industrial Area, 1515Nong，Yuandong Road Fengxian District, Shanghai ,China
Contact:+86-0311-84455288-844
Address:Mayu Industrial Park, Jinzhou, Hebei, China.
Contact:+86-0512-69209969
Address:Room 317,Lushan Road,Suzhou New District,Jiangsu Province,China.
Taizhou Chemedir Biopharm-tech Co., Ltd
Contact:+86 523 86200218
Address:G09, No. 1 Avenue China Medical City, Taizhou,Jiangsu, China
Doi:10.1246/bcsj.70.1141
(1997)Doi:10.1021/op7001722
(2008)Doi:10.1016/S0960-894X(01)00672-2
(2002)Doi:10.1021/jm970676d
(1998)Doi:10.1021/jo970535j
(1997)Doi:10.1002/jps.2600571049
(1968)
